Added-value of ancillary imaging features for differentiating hepatocellular carcinoma from intrahepatic mass-forming cholangiocarcinoma on Gd-BOPTA-enhanced MRI in LI-RADS M.
Objective: To identify the reliable imaging features and added-value of ancillary imaging features for differentiating hepatocellular carcinoma (HCC) and intrahepatic mass-forming cholangiocarcinoma (IMCC) assigned to LI-RADS M on Gd-BOPTA-enhanced MRI. Methods: This retrospective study included 116...
| Publicado en: | Abdominal Radiology Vol. 47; no. 3; pp. 957 - 969 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155380755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155380755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Mar2022 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155380755 154363687 155380755 155380755 10.1007/s00261-021-03380-6 155380755 ppf: 957 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Added-value of ancillary imaging features for differentiating hepatocellular carcinoma from intrahepatic mass-forming cholangiocarcinoma on Gd-BOPTA-enhanced MRI in LI-RADS M. aug: au: Zheng, Wanjing Huang, Hongjie She, Dejun Xiong, Meilian Chen, Xiaodan Lin, Xiaojun Cao, Dairong affil: Department of Radiology, First Affiliated Hospital of Fujian Medical University, 350005, Fuzhou, Fujian, China sug: subj: Carcinoma, Hepatocellular Diagnosis Cholangiocarcinoma Diagnosis Diagnostic Imaging Methods Magnetic Resonance Imaging Methods Ancillary Services, Hospital Human Value-Based Health Care Retrospective Design Pretest-Posttest Design Univariate Statistics Multiple Logistic Regression ROC Curve Odds Ratio Confidence Intervals Sensitivity and Specificity Contrast Media Diagnosis, Differential ab: Objective: To identify the reliable imaging features and added-value of ancillary imaging features for differentiating hepatocellular carcinoma (HCC) and intrahepatic mass-forming cholangiocarcinoma (IMCC) assigned to LI-RADS M on Gd-BOPTA-enhanced MRI. Methods: This retrospective study included 116 liver observations assigned to LI-RADS M, including 82 HCC and 34 IMCC histologically confirmed. Before and after adding ancillary imaging features, all variables with a p-value of < 0.05 in univariable analysis were entered into a multivariable logistic regression analysis to build diagnostic model 1 and model 2 to find reliable predictors of HCC diagnosis. Receiver operating characteristic (ROC) analysis and the DeLong test were used to compare the two models. Results: Forty-nine of 82(59.8%) HCCs had a considerably higher frequency of enhancing "capsule" compared with IMCCs (p < 0.001). Based on LI-RADS major and LR-M features and clinical-pathologic factors, an elevated AFP level (OR = 10.676, 95%CI = 2.125–4.470, p = 0.004) and enhancing "capsule" (OR = 20.558, 95%CI = 4.470–94.550, p < 0.001) were extracted as independent risk factors in Model 1. After adding ancillary imaging features, Male (OR = 23.452, 95%CI = 1.465–375.404, p = 0.026), enhancing "capsule" (OR = 13.161, 95%CI = 1.725–100.400, p = 0.013), septum (OR = 17.983, 95%CI = 1.049–308.181, p = 0.046), small-scale central HBP hyperintensity (OR = 44.386, 95%CI = 1.610–1223.484, p = 0.025) were confirmed as independent significant variables associated with HCC. Model 2 demonstrated significantly superior AUC (0.918 vs 0.845, p = 0.021) compared with Model 1. When any two or more predictors in model 2 were satisfied, sensitivity was 91.46%, and accuracy was at the top (87.93%). Conclusion: Enhancing "capsule" was a reliable imaging feature to help identify HCC. Adding ancillary imaging features improved sensitivity and accuracy for HCC diagnosis with differentiation from IMCC in LR-M. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|