Liver fibrosis quantification.
Liver fibrosis (LF) is the wound healing response to chronic liver injury. LF is the endpoint of chronic liver disease (CLD) regardless of etiology and the single most important determinant of long-term liver-related clinical outcomes. Quantification of LF is important for staging, to evaluate respo...
| Publicado en: | Abdominal Radiology Vol. 47; no. 3; pp. 1032 - 1053 |
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| Autores principales: | , |
| Formato: | diagnostic images pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155380764&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155380764 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Mar2022 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155380764 154633670 155380764 155380764 10.1007/s00261-021-03396-y 155380764 ppf: 1032 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Liver fibrosis quantification. aug: au: Venkatesh, Sudhakar K. Torbenson, Michael S. affil: Abdominal Imaging Division, Department of Radiology, Mayo Clinic, 200, First Street SW, 55905, Rochester, MN, USA sug: subj: Liver Injuries Liver Diseases Complications Liver Cirrhosis Ultrasonography Liver Cirrhosis Radiography Severity of Illness Evaluation Biopsy Fibrinolysis Biological Markers Noninvasive Procedures Disease Progression Tomography, X-Ray Computed ab: Liver fibrosis (LF) is the wound healing response to chronic liver injury. LF is the endpoint of chronic liver disease (CLD) regardless of etiology and the single most important determinant of long-term liver-related clinical outcomes. Quantification of LF is important for staging, to evaluate response to treatment and to predict outcomes. LF is traditionally staged by liver biopsy. However, liver biopsy is invasive and suffers from sampling errors when biopsy size is inadequate; therefore, non-invasive tests (NITs) have found important roles in clinical care. NITs include simple laboratory-based serum tests, panels of serum tests, and imaging biomarkers. NITs are validated against the liver biopsy and will be used in the future for evaluation of nearly all CLDs with invasive liver biopsy reserved for some cases. Both serum tests and some imaging biomarkers such as elastography are currently used clinically as surrogate markers for LF. Several other imaging biomarkers are still considered research and awaiting clinical application in the future. As the evaluation of imaging biomarkers will likely become the norm in the future, understanding pathogenesis of LF is important. Knowledge of properties measured by imaging biomarkers and its correlation with LF is important to understand the application of NITs by abdominal radiologists. In this review, we present a brief overview of pathogenesis of LF, spatiotemporal evolution of LF in different CLD, and severity assessment with liver biopsy. This will be followed by a brief discussion on properties measured by imaging biomarkers and their relationship to the LF. pubtype: Academic Journal doctype: diagnostic images pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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