Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study.
There is evidence to suggest that soy may be beneficial for prostate cancer patients, but few randomized trials have addressed this. We examined the effect of 6–8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA > 0.1 ng/ml) within three years o...
| Publicado en: | Nutrition & Cancer Vol. 74; no. 2; pp. 555 - 565 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Taylor & Francis Ltd
2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155436630&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155436630 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 155436630 149464547 155436630 155436630 10.1080/01635581.2021.1903949 155436630 ppf: 555 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Randomized, Placebo-Controlled Six-Month Intervention Study of Soy Protein Isolate in Men with Biochemical Recurrence after Radical Prostatectomy: A Pilot Study. aug: au: Bosland, Maarten C. Schmoll, Joanne Watanabe, Hiroko Randolph, Carla Kato, Ikuko affil: Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA sug: subj: Soy Proteins Therapeutic Use Dietary Supplementation Neoplasm Recurrence, Local Prevention and Control Prostatic Neoplasms Surgery Prostatectomy, Radical Prostate-Specific Antigen Blood Treatment Outcomes Evaluation Human Randomized Controlled Trials Pilot Studies Placebos Administration and Dosage Male Random Assignment Genistein Administration and Dosage Isoflavones Administration and Dosage Caseins Administration and Dosage Pretest-Posttest Design Genistein Blood Cholesterol Blood Comparative Studies Middle Age Aged Soy Proteins Administration and Dosage Middle Aged: 45-64 years Aged: 65+ years Male ab: There is evidence to suggest that soy may be beneficial for prostate cancer patients, but few randomized trials have addressed this. We examined the effect of 6–8 mo soy protein supplementation on prostate specific antigen (PSA) serum levels in men who recurred (PSA > 0.1 ng/ml) within three years of prostatectomy. Sixteen men were randomized to 20 g soy protein (∼24–26/day genistein; ∼40–43/day total isoflavones) or casein placebo. PSA was measured at base line and at 1, 2, 4, and 6–8 mo. Serum genistein levels greatly increased from baseline and cholesterol decreased in the soy group. In both treatment arms PSA increased similarly and PSA doubling times were not different over the 6–8 mo study duration. Two subjects in each group had stable PSA. A literature search for clinical studies of soy, isoflavones, and PSA revealed that supplementation with soy or isoflavones did not affect PSA in virtually all clinical studies identified. Although this study is too small to draw a definitive conclusion on the effect of soy protein on PSA in men with biochemical failure, the null finding in this study is consistent with the results of virtually all reports of soy and soy isoflavones in the literature. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|