Muricazine, a new hydrazine derivative from Ranunculus muricatus L. with antioxidant, lipoxygenase and urease inhibitory activities.
Ranunculus muricatus L., an important member of family Ranunculaceae upon submission to phytochemical studies, led to the isolation of a novel natural hydrazine derivative, muricazine (1). Chemical structure of the compound was established with the aid of advanced spectroscopic techniques. It was ev...
| Publicado en: | Natural Product Research Vol. 36; no. 4; pp. 961 - 967 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Ranunculus muricatus L., an important member of family Ranunculaceae upon submission to phytochemical studies, led to the isolation of a novel natural hydrazine derivative, muricazine (1). Chemical structure of the compound was established with the aid of advanced spectroscopic techniques. It was evaluated for in vitro antioxidant, lipoxygenase, and urease (jack-bean) inhibitory activities. Results suggested that compound 1 could scavenge the DPPH free radical (42.1 ± 0.12 μM) to a great extent as compared to the standard (40.6 ± 0.91 μM). However, it showed moderate inhibitory potential against lipoxygenase (65.2 ± 0.45 μM) and urease (54.8 ± 0.23 μM) enzymes. |
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