Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease.
Background: To investigate changes in gait performance over time and how these changes are associated with the decline in structural network efficiency and cognition in older patients with cerebral small vessel disease (SVD).Methods: In a prospective, single-center cohort with 217 older participants...
| Published in: | Journals of Gerontology Series A: Biological Sciences & Medical Sciences Vol. 77; no. 3; pp. 554 - 561 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Oxford University Press / USA
Mar2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155553778&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155553778 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10795006 JGA jtl: Journals of Gerontology Series A: Biological Sciences & Medical Sciences issn: 10795006 maglogo: N pubinfo: dt: Mar2022 vid: 77 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 155553778 155553778 NLM34459914 155553778 10.1093/gerona/glab247 NLM34459914 155553778 ppf: 554 ppct: 7 formats: tig: atl: Longitudinal Relation Between Structural Network Efficiency, Cognition, and Gait in Cerebral Small Vessel Disease. aug: au: Cai, Mengfei Jacob, Mina A Norris, David G Leeuw, Frank-Erik de Tuladhar, Anil M de Leeuw, Frank-Erik affil: Department of Neurology, Radboud University Medical Center , Nijmegen , The Netherlands sug: subj: Cerebral Small Vessel Diseases Complications Brain Cerebral Small Vessel Diseases Human Magnetic Resonance Imaging Cognition Prospective Studies Gait Aged Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source Checklists Aged: 65+ years ab: Background: To investigate changes in gait performance over time and how these changes are associated with the decline in structural network efficiency and cognition in older patients with cerebral small vessel disease (SVD).Methods: In a prospective, single-center cohort with 217 older participants with SVD, we performed 1.5T MRI scans, cognitive tests, and gait assessments evaluated by Timed UP and Go (TUG) test twice over 4 years. We reconstructed the white matter network for each subject based on diffusion tensor imaging tractography, followed by graph-theoretical analyses to compute the global efficiency. Conventional MRI markers for SVD, that is, white matter hyperintensity (WMH) volume, number of lacunes, and microbleeds, were assessed.Results: Baseline global efficiency was not related to changes in gait performance, while decline in global efficiency over time was significantly associated with gait decline (ie, increase in TUG time), independent of conventional MRI markers for SVD. Neither baseline cognitive performance nor cognitive decline was associated with gait decline.Conclusions: We found that disruption of the white matter structural network was associated with gait decline over time, while the effect of cognitive decline was not. This suggests that structural network disruption has an important role in explaining the pathophysiology of gait decline in older patients with SVD, independent of cognitive decline. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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