A design of forceps-type coincidence radiation detector for intraoperative LN diagnosis: clinical impact estimated from LNs data of 20 esophageal cancer patients.
Purpose: To reduce postoperative complications, intraoperative lymph node (LN) diagnosis with 18F-fluoro-2-deoxy-D-glucose (FDG) is expected to optimize the extent of LN dissection, leading to less invasive surgery. However, such a diagnostic device has not yet been realized. We proposed the concept...
| Publicado en: | Annals of Nuclear Medicine Vol. 36; no. 3; pp. 285 - 293 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155624926&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155624926 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09147187 1CFC jtl: Annals of Nuclear Medicine issn: 09147187 maglogo: N pubinfo: dt: Mar2022 vid: 36 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155624926 155624926 NLM34843102 10.1007/s12149-021-01701-9 NLM34843102 155624926 ppf: 285 ppct: 8 formats: tig: atl: A design of forceps-type coincidence radiation detector for intraoperative LN diagnosis: clinical impact estimated from LNs data of 20 esophageal cancer patients. aug: au: Takahashi, Miwako Yoshimura, Shuntaro Takyu, Sodai Aikou, Susumu Okumura, Yasuhiro Yagi, Koichi Fukayama, Masashi Momose, Toshimitsu Seto, Yasuyuki Yamaya, Taiga affil: Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, 263-8555, Chiba, Japan sug: subj: Fludeoxyglucose F 18 Esophageal Neoplasms Surgery Esophageal Neoplasms Lymph Nodes Pathology Neoplasm Metastasis Neoplasm Staging Surgical Instruments Impact of Events Scale Scales ab: Purpose: To reduce postoperative complications, intraoperative lymph node (LN) diagnosis with 18F-fluoro-2-deoxy-D-glucose (FDG) is expected to optimize the extent of LN dissection, leading to less invasive surgery. However, such a diagnostic device has not yet been realized. We proposed the concept of coincidence detection wherein a pair of scintillation crystals formed the head of the forceps. To estimate the clinical impact of this detector, we determined the cut-off value using FDG as a marker for intraoperative LN diagnosis in patients with esophageal cancer, the specifications needed for the detector, and its feasibility using numerical simulation.Methods: We investigated the dataset including pathological diagnosis and radioactivity of 1073 LNs resected from 20 patients who underwent FDG-positron emission tomography followed by surgery for esophageal cancer on the same day. The specifications for the detector were determined assuming that it should measure 100 counts (less than 10% statistical error) or more within the intraoperative measurement time of 30 s. The detector sensitivity was estimated using GEANT4 simulation and the expected diagnostic ability was calculated.Results: The cut-off value was 620 Bq for intraoperative LN diagnosis. The simulation study showed that the detector had a radiation detection sensitivity of 0.96%, which was better than the estimated specification needed for the detector. Among the 1035 non-metastatic LNs, 815 were below the cut-off value.Conclusion: The forceps-type coincidence detector can provide sufficient sensitivity for intraoperative LN diagnosis. Approximately 80% of the prophylactic LN dissections in esophageal cancer can be avoided using this detector. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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