Role of the hypoxia-inducible factor (HIF) in the process of neurogenesis at the hippocampal level.
Hypoxia-induced factor 1 (HIF-1) plays a fundamental role in the response to low oxygen tension, since it regulates the expression of a wide variety of genes, whose products participate in processes such as angiogenesis, energy metabolism, erythropoiesis, and cell proliferation as well as in the pro...
| Publicado en: | Revista Mexicana de Neurociencia Vol. 23; no. 2; pp. 71 - 78 |
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| Formato: | Artículo |
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Academia Mexicana de Neurologia
Mar/Apr2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=155648023&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 155648023 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 16655044 R1Q jtl: Revista Mexicana de Neurociencia issn: 16655044 maglogo: N pubinfo: dt: Mar/Apr2022 vid: 23 iid: 2 pid: 20851 pub: Academia Mexicana de Neurologia artinfo: ui: 155648023 10.24875/RMN.21000020 ppf: 71 ppct: 7 formats: fmt: @attributes: type: P size: 506KB tig: atl: Role of the hypoxia-inducible factor (HIF) in the process of neurogenesis at the hippocampal level. aug: au: Ramirez-Rincón, Clara L. affil: School of Health Sciences, University of the Valley of Mexico, Zapopan, Jalisco, Mexico su: Hypoxemia Neovascularization Hippocampus (Brain) Developmental neurobiology Energy metabolism Erythropoiesis Central nervous system Catenins sug: subj: Hypoxemia Neovascularization Hippocampus (Brain) Developmental neurobiology Energy metabolism Erythropoiesis Central nervous system Catenins keyword: HIF Hippocampus Hypoxic Neurogénesis Wnt-catenin Hipocampo Hipoxia Wnt-catenina ab: Hypoxia-induced factor 1 (HIF-1) plays a fundamental role in the response to low oxygen tension, since it regulates the expression of a wide variety of genes, whose products participate in processes such as angiogenesis, energy metabolism, erythropoiesis, and cell proliferation as well as in the process of neurogenesis, which involves various stages, such as proliferation of neuronal stem cells, migration, differentiation, survival of new neurons, and integration of the same. Among the many intrinsic and extrinsic molecular signals that regulate the production of new neurons from progenitor cells in the adult in the central nervous system (CNS), hypoxic damage plays an important role in the maintenance and function of stem cells in development and disease. El factor 1 inducido por hipoxia (HIF-1) juega un papel fundamental en la respuesta a la baja tensión de oxígeno, ya que regula la expresión de una amplia variedad de genes cuyos productos participan en procesos como la angiogénesis, el metabolismo energético, la eritropoyesis y la proliferación celular. También participa en el proceso de neurogénesis, que involucra diversas etapas, como la proliferación de células madre neuronales, migración, diferenciación, supervivencia de nuevas neuronas e integración de las mismas. Entre las muchas señales moleculares intrínsecas y extrínsecas que regulan la producción de nuevas neuronas a partir de células progenitoras en el adulto en el sistema nervioso central (SNC), el daño hipóxico juega un papel importante en el mantenimiento y la función de las células madre en el desarrollo y la enfermedad. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Mexicana de Neurociencia holder: Academia Mexicana de Neurologia dt: @attributes: year: 2022 holdings: @attributes: islocal: N |
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