Evaluation of macular and peripapillary vascular parameter change in healthy subjects after caffeine intake using optical coherence tomography angiography.
Purpose: To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions and to analyze the correlations of vascular properties of these two interlinked regions in healthy volunteers using optical coherence tomography angiography (OCTA).Methods: In this prospective...
| Publicado en: | Indian Journal of Ophthalmology Vol. 70; no. 3; pp. 879 - 890 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Mar2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155650029&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155650029 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03014738 1BRZ jtl: Indian Journal of Ophthalmology issn: 03014738 maglogo: N pubinfo: dt: Mar2022 vid: 70 iid: 3 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 155650029 155650029 NLM35225536 155650029 10.4103/ijo.IJO_1989_21 NLM35225536 155650029 ppf: 879 ppct: 11 formats: tig: atl: Evaluation of macular and peripapillary vascular parameter change in healthy subjects after caffeine intake using optical coherence tomography angiography. aug: au: Yilmaz Tugan, Busra Subasi, Sevgi Pirhan, Dilara Karabas, Levent Yuksel, Nursen Kucuk, Kubra Kucuk, Kubra Demirci affil: Department of Ophthalmology, Kocaeli University Medical Faculty, Kocaeli sug: subj: Caffeine Pharmacodynamics Tomography, Optical Coherence Methods Research Subjects Prospective Studies Angiography Methods Retina Human Comparative Studies Multicenter Studies Randomized Controlled Trials Evaluation Research Validation Studies ab: Purpose: To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions and to analyze the correlations of vascular properties of these two interlinked regions in healthy volunteers using optical coherence tomography angiography (OCTA).Methods: In this prospective randomized, double-masked, placebo-controlled study, 120 participants were grouped into two groups: sixty subjects as a study group, which received caffeine and sixty subjects as a placebo group, which received a placebo. OCTA imaging was performed at baseline and 1 h after drug intake. Changes in macular and radial peripapillary capillary (RPC) vessel densities (VD) and foveal avascular zone (FAZ) parameters and correlation of these parameters were analyzed.Results: Baseline macular and RPC VD and FAZ parameters showed no significant difference between study and placebo groups (P > 0.05 for all). VD parameters in all segments of superficial and deep macular regions and peripapillary region showed a statistically significant decrease after caffeine intake (P < 0.001 for all). All macular superficial VD parameters showed a positive correlation with deep perifovea VD (P < 0.05 for all). Also, superficial perifovea VD was positively correlated with all deep macular VD parameters except deep fovea VD (P < 0.05 for all).Conclusion: We show that caffeine causes a decrease in macular and peripapillary vessel densities in healthy subjects, and correlations were observed between macular and peripapillary VD parameters. We believe that future studies are needed to support the effect of caffeine on peripapillary VD and the idea of using deep perifovea VD as the main parameter to estimate superficial macular parameters. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|