Influence of alcohol and acetaldehyde on cognitive function: findings from an alcohol clamp study in healthy young adults.
Aims: To investigate the acute effects of intravenous alcohol and its metabolite acetaldehyde on cognitive function in healthy individuals. Design Experimental pre‐test/post‐test design. Setting: Kurihama Medical and Addiction Center, Japan. Participants: A total of 298 healthy Japanese people age 2...
| Publicado en: | Addiction Vol. 117; no. 4; pp. 934 - 946 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155656576&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155656576 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Apr2022 vid: 117 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155656576 153729304 155656576 155656576 10.1111/add.15733 155656576 ppf: 934 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Influence of alcohol and acetaldehyde on cognitive function: findings from an alcohol clamp study in healthy young adults. aug: au: Ueno, Fumihiko Matsushita, Sachio Hara, Sachiko Oshima, Shunji Roh, Sungwon Ramchandani, Vijay A. Mimura, Masaru Uchida, Hiroyuki affil: National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Japan sug: subj: Cognition Evaluation Alcohols Administration and Dosage Aldehydes Administration and Dosage Human Japan Female Male Young Adult Experimental Studies Pretest-Posttest Design Academic Medical Centers Japanese Persons Alcohols Blood Time Factors Attention Memory Reaction Time Validity Outcome Assessment Repeated Measures Analysis of Covariance Multiple Regression Post Hoc Analysis Data Analysis Software Descriptive Statistics Female Male ab: Aims: To investigate the acute effects of intravenous alcohol and its metabolite acetaldehyde on cognitive function in healthy individuals. Design Experimental pre‐test/post‐test design. Setting: Kurihama Medical and Addiction Center, Japan. Participants: A total of 298 healthy Japanese people age 20 to 24 years. Measurements Participants underwent an intravenous alcohol infusion with a target blood alcohol concentration (BAC) of 0.50 mg/mL for 180 minutes. Participants completed the continuous performance test (CPT) for sustained attention, the paced auditory serial addition test (PASAT) for working memory, and the reaction time test (RTT) for speed/accuracy, along with the blood test for BAC and blood acetaldehyde concentration (BAAC) at baseline, 60 and 180 minutes. Findings Although the target BAC was maintained during the infusion, BAAC peaked at 30 minutes and then gradually declined (η2 = 0.18, P < 0.01). The CPT scores worsened, and the changes between 0 and 60 minutes were correlated with BAAC (correct detection, η2 = 0.09, P < 0.01; r = −0.34, P < 0.01; omission errors, η2 = 0.08, P < 0.01; r = 0.34, P < 0.01). PASAT scores improved through 180 minutes, whereas the changes between 0 and 60 minutes were negatively correlated with BAAC (task one, η2 = 0.02, P < 0.01; r = −0.25, P < 0.01; task two, η2 = 0.03, P < 0.01; r = −0.28, P < 0.01). Although RTTs worsened, they were not associated with BAC or BAAC. None of these comparisons maintained the time effect after controlling for body height. Conclusions: Acetaldehyde exposure following acute intravenous alcohol appears to have a negative impact on sustained attention and working memory, whereas there seems to be only a minor effect of moderate alcohol concentration on speed and accuracy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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