Gross Total Resection of Childhood Intracranial Ependymoma is a Critically Important Factor in Survival.
OBJECTIVE: This study aimed to evaluate the effect of prognostic factors and treatment on survival in childhood intracranial ependymoma. METHODS: In the past two decades, 28 patients with pediatric intracranial ependymoma who received postoperative radiotherapy in our institute were evaluated statis...
| Publicado en: | Turkish Journal of Oncology / Türk Onkoloji Dergisi Vol. 37; no. 1; pp. 60 - 67 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
KARE Publishing
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155672142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155672142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13007467 B6JE jtl: Turkish Journal of Oncology / Türk Onkoloji Dergisi issn: 13007467 maglogo: N pubinfo: dt: 2022 vid: 37 iid: 1 pid: 62027 pub: KARE Publishing artinfo: ui: 155672142 155672142 155672142 10.5505/tjo.2021.3378 155672142 ppf: 60 ppct: 7 formats: tig: atl: Gross Total Resection of Childhood Intracranial Ependymoma is a Critically Important Factor in Survival. aug: au: AKSOY, Rahmi Atıl ŞENGÜN, Yasemin AKSU, Melek Gamze GÜLER, Elif KAZAN, Saim GENÇ, Mine affil: Department of Radiation Oncology, Akdeniz University Faculty of Medicine, Antalya-Turkey sug: subj: Glioma Surgery Childhood Neoplasms Surgery Glioma Prognosis Human Progression-Free Survival Kaplan-Meier Estimator Turkiye Glioma Radiotherapy Infant Child, Preschool Child Adolescence Neoplasm Grading Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years ab: OBJECTIVE: This study aimed to evaluate the effect of prognostic factors and treatment on survival in childhood intracranial ependymoma. METHODS: In the past two decades, 28 patients with pediatric intracranial ependymoma who received postoperative radiotherapy in our institute were evaluated statistically in terms of prognostic factors and survival. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Possible prognostic factors, such as sex, histopathological grade, the extent of resection, tumor location, spinal metastasis, and chemotherapy were also analyzed by log-rank test. RESULTS: Median age at diagnosis was 4 years (range, 1-17 years). Eighteen patients had infratentorial tumor, and 19 patients had Grade III tumor. Gross total resections (GTRs) were performed in 16 patients. The median clinical follow-up time was 66.9 months (range, 8-253 months). The estimated 5-year PFS and OS rates are 38% and 55%, respectively. The extent of resection was found the only prognostic factor associated with improved PFS and OS. Other factors, such as gender, histopathological grade, tumor location, spinal metastasis, and chemotherapy, showed no statistically significant effect on survival outcomes. CONCLUSION: A multidisciplinary approach is required in the management of pediatric intracranial ependymomas. GTR is a crucial prognostic factor on survival. The lack of aggressive salvage treatments may result in worse survival. Future trials are needed to investigate molecular classification and individualized treatment algorithms. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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