Value of ultra-high field MRI in patients with suspected focal epilepsy and negative 3 T MRI (EpiUltraStudy): protocol for a prospective, longitudinal therapeutic study.
Purpose : Resective epilepsy surgery is a well-established, evidence-based treatment option in patients with drug-resistant focal epilepsy. A major predictive factor of good surgical outcome is visualization and delineation of a potential epileptogenic lesion by MRI. However, frequently, these lesio...
| Published in: | Neuroradiology Vol. 64; no. 4; pp. 753 - 765 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | diagnostic images protocol tables/charts Journal Article |
| Published: |
Springer Nature
Apr2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155691314&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155691314 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Apr2022 vid: 64 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155691314 154481816 155691314 155691314 10.1007/s00234-021-02884-8 155691314 ppf: 753 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Value of ultra-high field MRI in patients with suspected focal epilepsy and negative 3 T MRI (EpiUltraStudy): protocol for a prospective, longitudinal therapeutic study. aug: au: van Lanen, R. H. G. J. Wiggins, C. J. Colon, A. J. Backes, W. H. Jansen, J. F. A. Uher, D. Drenthen, G. S. Roebroeck, A. Ivanov, D. Poser, B. A. Hoeberigs, M. C. van Kuijk, S. M. J. Hoogland, G. Rijkers, K. Wagner, G. L. Beckervordersandforth, J. Delev, D. Clusmann, H. Wolking, S. Klinkenberg, S. affil: Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands sug: subj: Magnetic Resonance Imaging Methods Epilepsy, Partial, Focal Surgery Prospective Studies ab: Purpose : Resective epilepsy surgery is a well-established, evidence-based treatment option in patients with drug-resistant focal epilepsy. A major predictive factor of good surgical outcome is visualization and delineation of a potential epileptogenic lesion by MRI. However, frequently, these lesions are subtle and may escape detection by conventional MRI (≤ 3 T). Methods: We present the EpiUltraStudy protocol to address the hypothesis that application of ultra-high field (UHF) MRI increases the rate of detection of structural lesions and functional brain aberrances in patients with drug-resistant focal epilepsy who are candidates for resective epilepsy surgery. Additionally, therapeutic gain will be addressed, testing whether increased lesion detection and tailored resections result in higher rates of seizure freedom 1 year after epilepsy surgery. Sixty patients enroll the study according to the following inclusion criteria: aged ≥ 12 years, diagnosed with drug-resistant focal epilepsy with a suspected epileptogenic focus, negative conventional 3 T MRI during pre-surgical work-up. Results: All patients will be evaluated by 7 T MRI; ten patients will undergo an additional 9.4 T MRI exam. Images will be evaluated independently by two neuroradiologists and a neurologist or neurosurgeon. Clinical and UHF MRI will be discussed in the multidisciplinary epilepsy surgery conference. Demographic and epilepsy characteristics, along with postoperative seizure outcome and histopathological evaluation, will be recorded. Conclusion: This protocol was reviewed and approved by the local Institutional Review Board and complies with the Declaration of Helsinki and principles of Good Clinical Practice. Results will be submitted to international peer-reviewed journals and presented at international conferences. Trial registration number: www.trialregister.nl: NTR7536. pubtype: Academic Journal doctype: diagnostic images protocol tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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