The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control.
Objective: Previous studies have demonstrated an association between gut microbiota composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the composition and function of the gut microbiome in adults with longstanding T1D or its association with host glycemic control.Rese...
| Publicado en: | Diabetes Care Vol. 45; no. 3; pp. 555 - 564 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
American Diabetes Association
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155722613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155722613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01495992 1G7 jtl: Diabetes Care issn: 01495992 maglogo: N pubinfo: dt: 2022 vid: 45 iid: 3 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 155722613 155722613 NLM35045174 10.2337/dc21-1656 NLM35045174 155722613 ppf: 555 ppct: 9 formats: tig: atl: The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control. aug: au: Shilo, Smadar Godneva, Anastasia Rachmiel, Marianna Korem, Tal Bussi, Yuval Kolobkov, Dmitry Karady, Tal Bar, Noam Wolf, Bat Chen Glantz-Gashai, Yitav Cohen, Michal Levin, Nehama Zuckerman Shehadeh, Naim Gruber, Noah Levran, Neriya Koren, Shlomit Weinberger, Adina Pinhas-Hamiel, Orit Segal, Eran Zuckerman Levin, Nehama affil: Pediatric Diabetes Clinic, Institute of Diabetes, Endocrinology and Metabolism, Rambam Health Care Campus, Haifa, Israel sug: ab: Objective: Previous studies have demonstrated an association between gut microbiota composition and type 1 diabetes (T1D) pathogenesis. However, little is known about the composition and function of the gut microbiome in adults with longstanding T1D or its association with host glycemic control.Research Design and Methods: We performed a metagenomic analysis of the gut microbiome obtained from fecal samples of 74 adults with T1D, 14.6 ± 9.6 years following diagnosis, and compared their microbial composition and function to 296 age-matched healthy control subjects (1:4 ratio). We further analyzed the association between microbial taxa and indices of glycemic control derived from continuous glucose monitoring measurements and blood tests and constructed a prediction model that solely takes microbiome features as input to evaluate the discriminative power of microbial composition for distinguishing individuals with T1D from control subjects.Results: Adults with T1D had a distinct microbial signature that separated them from control subjects when using prediction algorithms on held-out subjects (area under the receiver operating characteristic curve = 0.89 ± 0.03). Linear discriminant analysis showed several bacterial species with significantly higher scores in T1D, including Prevotella copri and Eubacterium siraeum, and species with higher scores in control subjects, including Firmicutes bacterium and Faecalibacterium prausnitzii (P < 0.05, false discovery rate corrected for all). On the functional level, several metabolic pathways were significantly lower in adults with T1D. Several bacterial taxa and metabolic pathways were associated with the host's glycemic control.Conclusions: We identified a distinct gut microbial signature in adults with longstanding T1D and associations between microbial taxa, metabolic pathways, and glycemic control indices. Additional mechanistic studies are needed to identify the role of these bacteria for potential therapeutic strategies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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