Transcranial Direct Current Stimulation May Reduce Prefrontal Recruitment During Dual Task Walking in Functionally Limited Older Adults – A Pilot Study.
Introduction: Transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (dlPFC) improves dual task walking in older adults, when tested just after stimulation. The acute effects of tDCS on the cortical physiology of walking, however, remains unknown. Methods: I...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 9 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Frontiers Media S.A.
3/11/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155750208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155750208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 3/11/2022 vid: 14 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 155750208 10.3389/fnagi.2022.843122 155750208 ppf: 1 ppct: 8 formats: tig: atl: Transcranial Direct Current Stimulation May Reduce Prefrontal Recruitment During Dual Task Walking in Functionally Limited Older Adults – A Pilot Study. aug: au: Jor'dan, Azizah J. Bernad-Elazari, Hagar Mirelman, Anat Gouskova, Natalia A. Lo, On-Yee Hausdorff, Jeffrey M. Manor, Brad affil: Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA, United States sug: subj: Transcranial Direct Current Stimulation Prefrontal Cortex Task Performance and Analysis Walking Geriatric Functional Assessment Pilot Studies Spectroscopy, Near-Infrared Paired T-Tests Deep Brain Stimulation Neural Pathways Human Male Female Aged Aged, 80 and Over Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: Transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (dlPFC) improves dual task walking in older adults, when tested just after stimulation. The acute effects of tDCS on the cortical physiology of walking, however, remains unknown. Methods: In a previous study, older adults with slow gait and executive dysfunction completed a dual task walking assessment before and after 20 min of tDCS targeting the left dlPFC or sham stimulation. In a subset of seven participants per group, functional near-infrared spectroscopy (fNIRS) was used to quantify left and right prefrontal recruitment defined as the oxygenated hemoglobin response to usual and dual task walking (ΔHbO2), as well as the absolute change in this metric from usual to dual task conditions (i.e., ΔHbO2 cost ). Paired t -tests examined pre- to post-stimulation differences in each fNIRS metric within each group. Results: The tDCS group exhibited pre- to post-stimulation reduction in left prefrontal ΔHbO2 cost (p = 0.03). This mitigation of dual task "cost" to prefrontal recruitment was induced primarily by a reduction in left prefrontal ΔHbO2 specifically within the dual task condition (p = 0.001), an effect that was observed in all seven participants within this group. Sham stimulation did not influence ΔHbO2 cost or ΔHbO2 in either walking condition (p > 0.35), and neither tDCS nor sham substantially influenced right prefrontal recruitment (p > 0.16). Discussion: This preliminary fNIRS data suggests that tDCS over the left dlPFC may modulate prefrontal recruitment, as reflected by a relative reduction in the oxygen consumption of this brain region in response to dual task walking. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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