Serum Galanin in Children with Autism Spectrum Disorder.
Recent studies have attempted to measure several biomarkers to understand the complex interactions of the anatomic systems that may be involved in autism spectrum disorder (ASD). In CNS, galanin takes part in a variety of pathological and physiological processes. Prior research has indicated it is i...
| Publicado en: | Child Psychiatry & Human Development Vol. 53; no. 2; pp. 300 - 307 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Apr2022
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=155779458&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 155779458 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0009398X CPH jtl: Child Psychiatry & Human Development issn: 0009398X maglogo: N pubinfo: dt: Apr2022 vid: 53 iid: 2 pid: 237 pub: Springer Nature artinfo: ui: 155779458 10.1007/s10578-021-01127-4 ppf: 300 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P size: 397KB tig: atl: Serum Galanin in Children with Autism Spectrum Disorder. aug: au: Saad, Khaled Abdel-Rahman, Ahmed A. Al-Atram, Abdulrahman A. Abdallah, Alam-Eldin M. Elhoufey, Amira Abdelsalam, Eman M. Nagiub Nigm, Dalia A. Elshora, Ola Ahmad, Ahmad Roshdy El-Tellawy, Mohamed M. Mahmoud, Khaled Hashim affil: Department of Pediatrics, Faculty of Medicine, Assiut University, 71516, Assiut, Egypt Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt Department of Psychiatry, College of Medicine, Majmaah University, Al Majmaah, Kingdom of Saudi Arabia Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt Department of Community Health Nursing, Alddrab University College, Jazan University, Jazan, Kingdom of Saudi Arabia Clinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt Department of Pediatrics, College of Medicine, Jouf University, Sakakah, Kingdom of Saudi Arabia su: Autism spectrum disorders Children with autism spectrum disorders Galanin Tourette syndrome sug: subj: Autism spectrum disorders Children with autism spectrum disorders Galanin Tourette syndrome keyword: Autism CARS Children Autism CARS Children ab: Recent studies have attempted to measure several biomarkers to understand the complex interactions of the anatomic systems that may be involved in autism spectrum disorder (ASD). In CNS, galanin takes part in a variety of pathological and physiological processes. Prior research has indicated it is involved in several neuropsychiatric disorders and has a role in inhibiting the neuronal firing and release of serotonin, norepinephrine, and acetylcholine. To date, serum galanin levels have not been investigated in the context of ASD. This study aimed, therefore, to compare the serum galanin levels of children with ASD and healthy controls and to reveal any association between galanin level and the severity of ASD, as well as other psychological and demographic parameters. Serum galanin levels were measured by radioimmunoassay in 116 children with ASD and 98 healthy children. We observed significantly increased serum concentrations of galanin in children with ASD relative to healthy children. Moreover, children with severe ASD had significantly higher galanin levels than those with less severe disease. We also confirmed significant positive correlations between galanin and psychiatric parameters in children with ASD. For the first time, we suggest a possible correlation between serum galanin and the degree of ASD severity. Increased galanin levels may play a role in the pathogenesis of ASD. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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