Muscle Area and Density Assessed by Abdominal Computed Tomography in Healthy Adults: Effect of Normal Aging and Derivation of Reference Values.
Background: A growing body of evidence has demonstrated the prognostic value of skeletal muscle area and quality measured by computed tomography (CT) as biomarkers of sarcopenia and frailty. However, there exists little data in normal healthy subjects to inform reference values and determine the eff...
| Publicado en: | Journal of Nutrition, Health & Aging Vol. 26; no. 3; pp. 243 - 247 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155870337&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155870337 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 12797707 2ZSX jtl: Journal of Nutrition, Health & Aging issn: 12797707 maglogo: N pubinfo: dt: Mar2022 vid: 26 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 155870337 155176412 155870337 155870337 10.1007/s12603-022-1746-3 155870337 ppf: 243 ppct: 4 formats: tig: atl: Muscle Area and Density Assessed by Abdominal Computed Tomography in Healthy Adults: Effect of Normal Aging and Derivation of Reference Values. aug: au: De Marco, D. Mamane, S. Choo, W. Mullie, L. Xue, X. Afilalo, M. Afilalo, Jonathan affil: Division of Internal Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada sug: subj: Muscle, Skeletal Physiology Aging Reference Values Tomography, X-Ray Computed Sex Factors Age Factors Human Female Male Young Adult Adult Middle Age Aged Prospective Studies Retrospective Design Nonparametric Statistics Comparative Studies Outcome Assessment Sarcopenia Body Weight Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: A growing body of evidence has demonstrated the prognostic value of skeletal muscle area and quality measured by computed tomography (CT) as biomarkers of sarcopenia and frailty. However, there exists little data in normal healthy subjects to inform reference values and determine the effects of advancing age and sex on CT muscle parameters. Methods: Abdominal CT images of patients (20–80 years of age) presenting to the emergency department with benign abdominal symptoms and no significant medical comorbidities were retrospectively collected from 2014 to 2017. Psoas and abdominal wall muscle area (PMA, WMA) and density (PMD, WMD) at the level of the L4 vertebrae were measured with the CoreSlicer.com web app. The normal reference range was computed by non-parameteric 2.5th and 97.5th percentiles stratified by sex and restricted by age to the younger subgroup (20–39 years of age). Results: The cohort consisted of 390 otherwise healthy patients (162 males, 228 females). The lower reference range for PMA was <22.0 cm2 in males and <11.1 cm2 in females, and for WMA was <112.2 cm2 in males and <75.6 cm2 in females. There was a graded decline observed in PMA and WMA among older compared to younger adults (especially ≥60 years of age) (P<0.001) and among females compared to males (P<0.001). There was also a graded decline observed in PMD and WMD among older compared to younger adults (P<0.001), irrespective of sex. Conclusion: This study has defined the normal reference values and age-associated down-trend for CT muscle parameters at L4 in a healthy population using an accessible web-based software, which help contextualize and interpret these imaging biomarkers of sarcopenia in clinical care. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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