Evidence for a hijacked brain reward system but no desensitized threat system in quitting-motivated smokers: An fMRI study.
Background and aims: Several aspects of how quitting-motivated tobacco use disorder (TUD) subjects and never-smokers differ in terms of reward and threat processing remain unresolved. We aimed to examine aberrant reward and threat processes in TUD and the association with smoking characteristics. De...
| Publicado en: | Addiction Vol. 117; no. 3; pp. 701 - 713 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155882845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155882845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Mar2022 vid: 117 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155882845 152483058 155882845 155882845 10.1111/add.15651 155882845 ppf: 701 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Evidence for a hijacked brain reward system but no desensitized threat system in quitting-motivated smokers: An fMRI study. aug: au: Kunas, Stefanie L. Stuke, Heiner Heinz, Andreas Ströhle, Andreas Bermpohl, Felix affil: Campus Charité Mitte, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany sug: subj: Reward Cues Smoking Complications Smoking Cessation Brain Physiology Magnetic Resonance Imaging Human Comparative Studies Brain Mapping Persons with Substance Use Disorders Non-Smokers Germany Correlational Studies Descriptive Statistics Adult Middle Age Female Male Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background and aims: Several aspects of how quitting-motivated tobacco use disorder (TUD) subjects and never-smokers differ in terms of reward and threat processing remain unresolved. We aimed to examine aberrant reward and threat processes in TUD and the association with smoking characteristics. Design: A between- and within-subjects functional magnetic resonance imaging (fMRI) experiment with a 2 (groups) 4 (stimulus type) factorial design. The experimental paradigm had four conditions: pictures of (1) cigarettes served as drug-related-positive cues, (2) food as alternative reward cues, (3) long-term consequences of smoking as drug-related-negative cues and (4) neutral pictures as control. Setting/participants: Adult participants (n = 38 TUD subjects and n = 42 neversmokers) were recruited in Berlin, Germany. Measurements: As contrasts of primary interest, the interactions of group stimulustype were assessed. Significance threshold correction for multiple testing was carried out with the family-wise error method. Correlation analyses were used to test the association with smoking characteristics. Findings: The 2 2 interaction of smoking status and stimulus type revealed activations in the brain reward system to drug-related-positive cues in TUD subjects (betweensubjects effect: P-values = 0.036). As a response to drug-related-negative cues, TUD subjects showed no reduced activation of the aversive brain network. Within the TUD group, a significant negative association was found between response of the aversive brain system to drug-related-negative cues (within-subjects effect: P-values = 0.021) and the number of cigarettes smoked per day (right insula r = -0.386, P = 0.024; left insula r = -0.351, P = 0.042; right ACC r = -0.359, P = 0.037). Conclusions: Moderate smokers with tobacco use disorder appear to have altered brain reward processing of drug-related-positive (but not negative) cues compared with never smokers. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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