Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy.
Background and Aims: Although English Stop Smoking Services routinely offer dual nicotine replacement therapy (NRT) to help pregnant women to quit smoking, little is known about how nicotine and tobacco smoke exposures following this compare with that from smoking. We compared, in pregnant women whe...
| Publicado en: | Addiction Vol. 117; no. 3; pp. 751 - 760 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155882851&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155882851 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Mar2022 vid: 117 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155882851 152527589 155882851 155882851 10.1111/add.15671 155882851 ppf: 751 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy. aug: au: Slaich, Bhavandeep Claire, Ravinder Emery, Joanne Lewis, Sarah Cooper, Sue Thomson, Ross Phillips, Lucy Kinahan-Goodwin, Darren Naughton, Felix McDaid, Lisa Clark, Miranda Dickinson, Anne Coleman, Tim affil: Division of Primary Care, University of Nottingham, Nottingham, UK sug: subj: Cotinine Analysis Saliva Analysis Carbon Monoxide Expiration Smoking In Pregnancy Nicotine Replacement Therapy In Pregnancy Human Pregnancy Female Expectant Mothers Secondary Analysis United Kingdom Confidence Intervals Smoking Cessation Descriptive Statistics Female ab: Background and Aims: Although English Stop Smoking Services routinely offer dual nicotine replacement therapy (NRT) to help pregnant women to quit smoking, little is known about how nicotine and tobacco smoke exposures following this compare with that from smoking. We compared, in pregnant women when smoking and after being offered dual NRT, saliva cotinine and exhaled carbon monoxide (CO) concentrations and numbers of daily cigarettes smoked. Design and Setting: Secondary analysis of data from three sequential, observational, mixed-methods cohort studies conducted as part of the Nicotine Replacement Effectiveness and Delivery in Pregnancy programme. Participants were recruited on-line or in Nottingham University Hospitals (UK) antenatal clinics between June 2019 and September 2020. Participants: Forty pregnant women, who agreed to try stopping smoking. Intervention: Participants were offered dual NRT, agreed a smoking quit date and received an intervention to improve adherence to NRT. Measurements: Saliva cotinine and exhaled CO concentrations and reported number of cigarettes smoked per day. Findings: There were no differences in saliva cotinine concentrations at baseline and day 7 post quit date [n = 20, mean difference = -32.31 ng/ml, 95% confidence interval (CI) = -68.11 to 3.5 ng/ml; P = 0.074, Bayes factor = 0.04]. There were reductions in the reported number of cigarettes smoked per day (n = 26, mean difference = -7 cigarettes, 95% CI = -8.35 to -5.42 cigarettes, P < 0.001) and concurrently in exhaled CO concentrations (n = 17, ratio of geometric means = 0.30 p.p.m., 95% CI = 0.17-0.52 p.p.m.; P < 0.001). Conclusion: Pregnant women who smoke and are offered dual nicotine replacement therapy (NRT) appear to show no change in their exposure to cotinine compared with their pre-NRT exposure levels but they report smoking fewer cigarettes, as validated by reductions in exhaled carbon monoxide concentrations. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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