Novel 1, 2, 4-Triazoles as Antifungal Agents.
The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most...
| Publicado en: | BioMed Research International pp. 1 - 40 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/22/2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155889694&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155889694 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 3/22/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155889694 155889694 155889694 10.1155/2022/4584846 155889694 ppf: 1 ppct: 39 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Novel 1, 2, 4-Triazoles as Antifungal Agents. aug: au: Kazeminejad, Zahra Marzi, Mahrokh Shiroudi, Abolfazl Kouhpayeh, Seyed Amin Farjam, Mojtaba Zarenezhad, Elham affil: Young Researchers and Elite Club, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran sug: subj: Heterocyclic Compounds Pharmacodynamics Antifungal Agents Drug Development Biological Availability Heterocyclic Compounds Analogs and Derivatives Drug Efficacy Molecular Structure Drug Resistance, Microbial ab: The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|