Low Abundance of Lactococcus lactis in Human Colorectal Cancer Is Associated with Decreased Natural Killer Cells.
A limited number of studies have demonstrated the role of Lactococcus lactis (L. lactis) in human colorectal cancers (CRCs). The association of L. lactis abundance with the density of natural killer (NK) cells has not been investigated before. In this study, the L. lactis abundance in 60 CRC specime...
| Published in: | Nutrition & Cancer Vol. 74; no. 3; pp. 938 - 947 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2022
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155930097&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155930097 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 155930097 151188100 155930097 155930097 10.1080/01635581.2021.1944649 155930097 ppf: 938 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Low Abundance of Lactococcus lactis in Human Colorectal Cancer Is Associated with Decreased Natural Killer Cells. aug: au: Li, Huan Du, Xinhao Yan, Li Tang, Zhenzhen Zhang, Ling Zheng, Qiao Zeng, Xianghao Chen, Guimei Yue, Huawen Fu, Xiangsheng affil: Department of Gastroenterology, The Central Hospital of Guangyuan City, Sichuan, China sug: subj: Colorectal Neoplasms Pathology Colorectal Neoplasms Microbiology Gram-Positive Bacteria Analysis Killer Cells, Natural Metabolism Human In Situ Hybridization RNA Fluorescent Antibody Technique Descriptive Statistics Disease Progression Pathology Comparative Studies Adenoma ab: A limited number of studies have demonstrated the role of Lactococcus lactis (L. lactis) in human colorectal cancers (CRCs). The association of L. lactis abundance with the density of natural killer (NK) cells has not been investigated before. In this study, the L. lactis abundance in 60 CRC specimens, 20 adenoma (AD) specimens, and 29 normal colorectal tissues (NCs) specimens was investigated using the fluorescence in situ hybridization of 16S ribosomal RNA. The density of NK cells was detected using immunofluorescence in 28 CRC specimens, 12 AD specimens, and 22 NC specimens. The presence of L. lactis in NCs (48.28%) was detected significantly higher than that in the AD (20.00%, P =.044) and CRC (23.33%, P =.018) specimens. The abundance of L. lactis in NCs (32.73 ± 7.24) was also found to be significantly higher than that in AD (8.91 ± 5.89, P =.029) and CRC (5.63 ± 1.67, P =.003) specimens. In addition, the density of NKp30+ NK cells in NCs (51.14 ± 4.84) was significantly higher than that in the AD (6.10 ± 1.31) and CRC (1.72 ± 0.40) specimens (P <.001). Moreover, a positive association of L. lactis abundance with NKp30+ NK cells density in the colorectal samples (P <.001) was observed. The low abundance of L. lactis in the CRC tissues was associated with the decreased NK cells, which suggested that this might contribute to the progression of CRC by decreasing the number of NK cells. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1944649 pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|