Automated Mathematical Algorithm for Quantitative Measurement of Strabismus Based on Photographs of Nine Cardinal Gaze Positions.

This study presents an automated algorithm that measures ocular deviation quantitatively using photographs of the nine cardinal points of gaze by means of deep learning (DL) and image processing techniques. Photographs were collected from patients with strabismus. The images were used as inputs for...

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Published in:BioMed Research International pp. 1 - 8
Main Authors: Kang, Yena Christina, Yang, Hee Kyung, Kim, Young Jae, Hwang, Jeong-Min, Kim, Kwang Gi
Format: equations & formulas pictorial research tables/charts Journal Article
Published: Wiley-Blackwell 3/24/2022
Online Access:View this record in EBSCOhost
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      dt: 3/24/2022
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2022/9840494
        155931072
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        atl: Automated Mathematical Algorithm for Quantitative Measurement of Strabismus Based on Photographs of Nine Cardinal Gaze Positions.
      aug:
        au:
          Kang, Yena Christina
          Yang, Hee Kyung
          Kim, Young Jae
          Hwang, Jeong-Min
          Kim, Kwang Gi
        affil: Department of Biomedical Engineering, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Republic of Korea
      sug:
        subj:
          Mathematics
          Algorithms
          Strabismus
          Photography
          Eye Movement Measurements
          Deep Learning
          Image Processing, Computer Assisted
          Human
          Quantitative Studies
          Cornea
          Descriptive Statistics
          Cost Benefit Analysis
          Diagnosis, Eye
      ab: This study presents an automated algorithm that measures ocular deviation quantitatively using photographs of the nine cardinal points of gaze by means of deep learning (DL) and image processing techniques. Photographs were collected from patients with strabismus. The images were used as inputs for the DL segmentation models that segmented the sclerae and limbi. Subsequently, the images were registered for the mathematical algorithm. Two-dimensional sclera and limbus were modeled, and the corneal light reflex points of the primary gaze images were determined. Limbus recognition was performed to measure the pixel-wise distance between the corneal reflex point and limbus center. The segmentation models exhibited high performance, with 96.88% dice similarity coefficient (DSC) for the sclera segmentation and 95.71% DSC for the limbus segmentation. The mathematical algorithm was tested on two cranial nerve palsy patients to evaluate its ability to measure and compare ocular deviation in different directions. These results were consistent with the symptoms of such disorders. This algorithm successfully measured the distance of ocular deviation in patients with strabismus. With complementation in the dimension calculations, we expect that this algorithm can be used further in clinical settings to diagnose and measure strabismus at a low cost.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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