Reverse Visually Guided Reaching in Patients with Parkinson's Disease.
In addition to motor symptoms such as difficulty in movement initiation and bradykinesia, patients with Parkinson's disease (PD) display nonmotor executive cognitive dysfunction with deficits in inhibitory control. Preoperative psychological assessments are used to screen for impulsivity that may be...
| Publicado en: | Parkinson's Disease (20420080) pp. 1 - 15 |
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| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/28/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155972709&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155972709 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20908083 B6DS jtl: Parkinson's Disease (20420080) issn: 20908083 maglogo: N pubinfo: dt: 3/28/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155972709 155972709 155972709 10.1155/2022/8132923 155972709 ppf: 1 ppct: 14 formats: tig: atl: Reverse Visually Guided Reaching in Patients with Parkinson's Disease. aug: au: Gaprielian, Pauline Scott, Stephen H. Levy, Ron affil: Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada sug: subj: Parkinson Disease Drug Therapy Parkinson Disease Surgery Saccades Psychomotor Performance Evaluation Task Performance and Analysis Dopamine Agents Therapeutic Use Antiparkinson Agents Therapeutic Use Deep Brain Stimulation Methods Treatment Outcomes Evaluation Human Comparative Studies Reaction Time Hypokinesia Proprioception Preoperative Care Drug Efficacy Postoperative Complications Risk Factors Deep Brain Stimulation Adverse Effects Descriptive Statistics Ontario Middle Age Aged Female Male Middle Aged: 45-64 years Aged: 65+ years Female Male ab: In addition to motor symptoms such as difficulty in movement initiation and bradykinesia, patients with Parkinson's disease (PD) display nonmotor executive cognitive dysfunction with deficits in inhibitory control. Preoperative psychological assessments are used to screen for impulsivity that may be worsened by deep brain stimulation (DBS) of the subthalamic nucleus (STN). However, it is unclear whether anti-Parkinson's therapy, such as dopamine replacement therapy (DRT) or DBS, which has beneficial effects on motor function, adversely affects inhibitory control or its domains. The detrimental effects of STN-DBS are more apparent when tasks test the inhibition of habitual prepotent responses or involve complex cognitive loads. Our goal was to use a reverse visually guided reaching (RVGR) task, a hand-based version of the antisaccade task, to simultaneously measure motor performance and response inhibition in subjects with PD. We recruited 55 healthy control subjects, 26 PD subjects receiving treatment with DRTs, and 7 PD subjects receiving treatment with STN-DBS and DRTs. In the RVGR task, a cursor moved opposite to the subject's hand movement. This was compared to visually guided reaching (VGR) where the cursor moved in the same direction as the subject's hand movement. Reaction time, mean speed, and direction errors (in RVGR) were assessed. Reaction times were longer, and mean speeds were slower during RVGR compared to VGR in all three groups but worse in untreated subjects with PD. Treatment with DRTs, DBS, or DBS + DRT improved the reaction time and speed on the RVGR task to a greater extent than VGR. Additionally, DBS or DBS + DRT demonstrated an increase in direction errors, which was correlated with decreased reaction time. These results show that the RVGR task quantifies the benefit of STN-DBS on bradykinesia and the concomitant reduction of proactive inhibitory control. The RVGR task has the potential to be used to rapidly screen for preoperative deficits in inhibitory control and to titrate STN-DBS, to maximize the therapeutic benefits on movement, and minimize impaired inhibitory control. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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