Xanthones and benzophenones isolated from the endophytic fungus Penicillium sp. ct-28 of Corydlis tomentella and their cytotoxic activity.
One new xanthone, griseophenexanthone A (1), one new benzophenone, digriseophene A (2), and 14 previously reported compounds were isolated from the culture of Penicillium sp. ct-28, an endophytic fungus of Corydlis tomentella. The structures of the isolated compounds were identified by an extensive...
| Publicado en: | Fitoterapia Vol. 157 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Mar2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156050295&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156050295 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Mar2022 vid: 157 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 156050295 156050295 156050295 10.1016/j.fitote.2022.105127 156050295 ppct: 1 formats: tig: atl: Xanthones and benzophenones isolated from the endophytic fungus Penicillium sp. ct-28 of Corydlis tomentella and their cytotoxic activity. aug: au: Ming, Qianliang Li, Yunong Jiang, Xiuxing Huang, Xiuning He, Yimo Qin, Lingyue Liu, Yanxia Tang, Yu Gao, Ning affil: Department of Pharmacognosy, College of Pharmacy, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China sug: subj: Heterocyclic Compounds Pharmacodynamics Ketones Pharmacodynamics Fungi Plants Cell Line, Tumor Drug Effects Antineoplastic Agents Pharmacodynamics Human Molecular Structure Cell Proliferation Drug Effects Descriptive Statistics Magnetic Resonance Spectroscopy Cell Cycle Drug Effects Apoptosis Drug Effects Dose-Response Relationship, Drug Transferases Drug Effects Caspases Drug Effects ab: One new xanthone, griseophenexanthone A (1), one new benzophenone, digriseophene A (2), and 14 previously reported compounds were isolated from the culture of Penicillium sp. ct-28, an endophytic fungus of Corydlis tomentella. The structures of the isolated compounds were identified by an extensive analysis of HRESIMS, 1D and 2D NMR. MTT assay showed that six xanthones (1 and 3 – 7) significantly inhibited cell proliferation in four cancer cell lines, with IC 50 values ranging from 18.12 ± 2.42 to 85.55 ± 7.66 μM. Our results showed that slight structural changes led to obvious activity differences among these compounds. We also investigated the effects of the six xanthones on cell cycle and apoptosis in human hepatoma HepG2 cells. Compound 7 caused cell cycle arrest at G1 phase, compounds 5 and 6 caused cell cycle arrest at S phase, whereas compounds 1 , 3 and 4 had no effects on cell cycle distribution. All six xanthones induced apoptosis in dose-dependent manners in HepG2 cells accompanied by degradation of PARP and activation of caspase 3. The structure–activity relationship analysis revealed that the effects of these xanthones on cell cycle and apoptosis in HepG2 cells were closely related to the substituent groups on their skeleton. Our studies provide novel insights for the structural optimization of xanthones in the development of new anticancer drugs. [Display omitted] pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|