Association between left atrial appendage fibrosis and thrombus formation: A histological approach.
Introduction: Although recent echocardiographic studies have suggested that left atrial appendage (LAA) remodeling contributes to the development of LAA thrombus (LAAT), histological evidence is absent. The objective of this study was to examine clinical parameters and histological findings to clari...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 33; no. 4; pp. 677 - 688 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156082542&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156082542 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Apr2022 vid: 33 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 156082542 154921223 156082542 156082542 10.1111/jce.15384 156082542 ppf: 677 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Association between left atrial appendage fibrosis and thrombus formation: A histological approach. aug: au: Miyauchi, Shunsuke Tokuyama, Takehito Uotani, Yukimi Miyamoto, Shogo Ikeuchi, Yoshihiro Okamura, Sho Okubo, Yousaku Katayama, Keijiro Takasaki, Taiichi Nakatani, Nobuhiro Matsudaira, Yorisato Furusho, Hisako Miyauchi, Mutsumi Takahashi, Shinya Nakano, Yukiko affil: Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan sug: subj: Fibrosis Atrial Fibrillation Physiopathology Thrombosis Risk Factors Disease Attributes Histology Risk Assessment Human Echocardiography, Transesophageal Descriptive Statistics Staining and Labeling ab: Introduction: Although recent echocardiographic studies have suggested that left atrial appendage (LAA) remodeling contributes to the development of LAA thrombus (LAAT), histological evidence is absent. The objective of this study was to examine clinical parameters and histological findings to clarify the factors involved in LAAT formation. Methods: A total of 64 patients (no atrial fibrillation [AF], N = 22; paroxysmal AF, N = 16; nonparoxysmal AF, N = 26) who underwent LAA excision during surgery were enrolled. Transthoracic and transesophageal echocardiography were performed before surgery. We evaluated the fibrosis burden (%) in the excised LAA sections with Azan–Mallory staining in patients with a LAAT compared with those without. Results: Patients with paroxysmal and non‐paroxysmal AF had a higher LAA fibrosis burden than those without AF (p =.005 and p <.0001, respectively). Among the patients enrolled, 16 had a LAAT and 15 of them had nonparoxysmal AF. Among the nonparoxysmal AF patients, those with a LAAT had significantly higher LAA fibrosis burden than those without (23.8% [14.8%–40.3%] vs. 12.8% [7.4%–18.2%], p =.004) and echocardiographic parameters of the left atrial volume index (R = 0.543, p =.01), LAA depth (R = 0.452, p =.02), and LAA flow velocity (R = − 0.487, p =.01) were correlated with the LAA fibrosis burden. Conclusion: This study provided histological evidence that LAA fibrosis is related to LAAT formation. Echocardiographic parameters of LAA remodeling and function were correlated with the LAA fibrosis burden. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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