A hidden Markov modeling approach for identifying tumor subclones in next-generation sequencing studies.
Allele-specific copy number alteration (ASCNA) analysis is for identifying copy number abnormalities in tumor cells. Unlike normal cells, tumor cells are heterogeneous as a combination of dominant and minor subclones with distinct copy number profiles. Estimating the clonal proportion and identifyin...
| Publicado en: | Biostatistics Vol. 23; no. 1; pp. 69 - 83 |
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| Autores principales: | , , |
| Formato: | equations & formulas review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2022
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| Acceso en línea: | Ver este registro en EBSCOhost |