Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents.
Background and aims: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults with AD and heavy‐drinking adolescents at age 19 and...
| Publicado en: | Addiction Vol. 117; no. 5; pp. 1312 - 1326 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156112703&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156112703 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: May2022 vid: 117 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 156112703 155454548 156112703 156112703 10.1111/add.15772 156112703 ppf: 1312 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents. aug: au: Ottino‐González, Jonatan Garavan, Hugh Albaugh, Matthew D. Cao, Zhipeng Cupertino, Renata B. Schwab, Nathan Spechler, Philip A. Allen, Nicholas Artiges, Eric Banaschewski, Tobias Bokde, Arun L. W. Burke Quinlan, Erin Brühl, Rüdiger Orr, Catherine Cousijn, Janna Desrivières, Sylvane Flor, Herta Foxe, John J. Fröhner, Juliane H. Goudriaan, Anna E. affil: Department of Psychiatry, University of Vermont College of Medicine, Burlington VT,, USA sug: subj: Brain Physiopathology Neural Pathways Physiopathology Alcoholism In Adolescence Drinking Behavior Structural Equation Modeling Binge Drinking In Adolescence Neurodevelopment Causal Modeling Brain Cortical Thickness Human Male Female Adult Adolescence Data Analysis Software Descriptive Statistics Young Adult Cross Sectional Studies Correlational Studies Europe Cluster Analysis Coefficient alpha Productivity Confidence Intervals Adult: 19-44 years Adolescent: 13-18 years Male Female ab: Background and aims: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults with AD and heavy‐drinking adolescents at age 19 and age 14, prior to substantial exposure to alcohol. Design Cross‐sectional sample of adults and a cohort of adolescents. Correlation matrices for cortical thicknesses across 68 regions were summarized with graph theoretic metrics. Setting and participants: A total of 745 adults with AD and 979 non‐dependent controls from 24 sites curated by the Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA)–Addiction consortium, and 297 hazardous drinking adolescents and 594 controls at ages 19 and 14 from the IMAGEN study, all from Europe. Measurements Metrics of network segregation (modularity, clustering coefficient and local efficiency) and integration (average shortest path length and global efficiency). Findings The younger AD adults had lower network segregation and higher integration relative to non‐dependent controls. Compared with controls, the hazardous drinkers at age 19 showed lower modularity [area‐under‐the‐curve (AUC) difference = −0.0142, 95% confidence interval (CI) = −0.1333, 0.0092; P‐value = 0.017], clustering coefficient (AUC difference = −0.0164, 95% CI = −0.1456, 0.0043; P‐value = 0.008) and local efficiency (AUC difference = −0.0141, 95% CI = −0.0097, 0.0034; P‐value = 0.010), as well as lower average shortest path length (AUC difference = −0.0405, 95% CI = −0.0392, 0.0096; P‐value = 0.021) and higher global efficiency (AUC difference = 0.0044, 95% CI = −0.0011, 0.0043; P‐value = 0.023). The same pattern was present at age 14 with lower clustering coefficient (AUC difference = −0.0131, 95% CI = −0.1304, 0.0033; P‐value = 0.024), lower average shortest path length (AUC difference = −0.0362, 95% CI = −0.0334, 0.0118; P‐value = 0.019) and higher global efficiency (AUC difference = 0.0035, 95% CI = −0.0011, 0.0038; P‐value = 0.048). Conclusions: Cross‐sectional analyses indicate that a specific structural covariance network profile is an early marker of alcohol dependence in adults. Similar effects in a cohort of heavy‐drinking adolescents, observed at age 19 and prior to substantial alcohol exposure at age 14, suggest that this pattern may be a pre‐existing risk factor for problematic drinking. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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