Pyoderma gangrenosum: a review of the clinical, mechanistic and therapeutic landscape.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that is uncommon and can sometimes be associated with systemic diseases. The pathophysiology underlying this condition is poorly understood, although recent advances suggest that local cutaneous abnormalities and functionally abnormal neutrophil...
| Publicado en: | Wound Practice & Research Vol. 30; no. 1; pp. 16 - 24 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156117167&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156117167 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18376304 639G jtl: Wound Practice & Research issn: 18376304 maglogo: N pubinfo: dt: Mar2022 vid: 30 iid: 1 pid: 66266 pub: Cambridge Publishing artinfo: ui: 156117167 156117167 156117167 10.33235/wpr.30.1.16-23 156117167 ppf: 16 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Pyoderma gangrenosum: a review of the clinical, mechanistic and therapeutic landscape. aug: au: Flora, Akshay Frew, John W. affil: Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia sug: subj: Pyoderma Gangrenosum Pyoderma Gangrenosum Diagnosis Pyoderma Gangrenosum Physiopathology Pyoderma Gangrenosum Therapy Pyoderma Gangrenosum Immunology Pyoderma Gangrenosum Symptoms Diagnosis, Differential Neutrophils Immunology Immunity Tacrolimus Administration and Dosage Ointments Administration and Dosage Administration, Topical Prednisolone Administration and Dosage Administration, Oral Cyclosporine Administration and Dosage Biological Therapy Wound Care Methods Diagnosis Inflammation Mediators Interleukins Antagonists and Inhibitors Inflammation Mediators Metabolism ab: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that is uncommon and can sometimes be associated with systemic diseases. The pathophysiology underlying this condition is poorly understood, although recent advances suggest that local cutaneous abnormalities and functionally abnormal neutrophils may trigger ongoing innate and adaptive immune system activity. PG remains a difficult condition to diagnose, mainly because it was previously seen as a diagnosis of exclusion, although newer diagnostic criteria have been proposed in order to overcome this. Furthermore, many patients do not respond to conventional therapy for PG once diagnosed, and experience persistence or worsening of their condition over time. The advent of immune targeted therapies, however, may represent a new treatment option for these patients. This review focuses on the clinical features and diagnosis of PG, as well as providing an update in our understanding of the pathophysiology and treatment options available for this debilitating condition. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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