Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury.
Objective. To explore the interhemispheric functional coordination following traumatic brain injury (TBI) and its association with posttraumatic anxiety and depressive symptoms. Methods. This was a combination of a retrospective cohort study and a cross-sectional observational study. We investigated...
| Publicado en: | BioMed Research International pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/7/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156201698&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156201698 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/7/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 156201698 156201698 156201698 10.1155/2022/3408660 156201698 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Decreased Interhemispheric Functional Connectivity and Its Associations with Clinical Correlates following Traumatic Brain Injury. aug: au: Song, Yu Han, Xi Li, Gaoyi Tong, Wusong Fan, Mingxia Chen, Xianzhen Yin, Jia Chen, Songyu Huang, Jingrong Gao, Dongming Gao, Liang Dong, Yan affil: Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China sug: subj: Brain Hemispheres Physiology Neural Pathways Physiology Functional Connectivity Brain Injuries Diagnosis Stress Disorders, Post-Traumatic Prevention and Control Anxiety Prevention and Control Depression Prevention and Control Human Retrospective Design Prospective Studies Cross Sectional Studies Nonexperimental Studies Gray Matter Anatomy and Histology Agenesis of Corpus Callosum Scales ROC Curve Pharmacokinetics Sensitivity and Specificity ab: Objective. To explore the interhemispheric functional coordination following traumatic brain injury (TBI) and its association with posttraumatic anxiety and depressive symptoms. Methods. This was a combination of a retrospective cohort study and a cross-sectional observational study. We investigated the functional coordination between hemispheres by voxel-mirrored homotopic connectivity (VMHC). Grey matter volumes were examined by voxel-based morphometry (VBM), and microstructural integrity of the corpus callosum (CC) was assessed by diffusion tension imaging (DTI). The anxiety and depressive symptoms were evaluated with the Hospital Anxiety and Depression Scale. Results. The VMHC values of the bilateral middle temporal gyrus (MTG) and orbital middle frontal gyrus (MFG) were significantly decreased in TBI patients versus the healthy controls. Weakened homotopic functional connectivity (FC) in the bilateral orbital MFG is moderate positively correlated with anxiety and depressive symptoms. The white matter integrity in the CC was extensively reduced in TBI patients. In the receiver operating characteristic analysis, the VMHC value of the orbital MFG could distinguish TBI from HC with an area under the curve of 0.939 (sensitivity of 1 and specificity of 0.867). Conclusion. TBI disrupts the interhemispheric functional and structural connection, which is correlated with posttraumatic mood disorders. These findings may serve as a clinical indicator for diagnosis. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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