Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study.
Background and project: Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether serum methionine metabolites levels are associated with NAFLD remains unclea...
| Publicado en: | Nutrition & Metabolism Vol. 19; no. 1; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
3/18/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156502341&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156502341 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 3/18/2022 vid: 19 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 156502341 156502341 156502341 10.1186/s12986-022-00647-7 156502341 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study. aug: au: Tang, Yi Chen, Xu Chen, Qian Xiao, Jinghe Mi, Jiaxin Liu, Qiannan You, Yiran Chen, Yuming Ling, Wenhua affil: Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhongshan Rd. 2, 510080, Guangzhou, Guangdong Province, People's Republic of China sug: subj: Methionine Blood Nonalcoholic Fatty Liver Disease Risk Factors Risk Assessment Metabolites Human Cross Sectional Studies Adult Middle Age Aged Anthropometry Nutritional Assessment Diagnostic Tests, Routine Abdomen Ultrasonography Multiple Logistic Regression S-Adenosylmethionine Blood Homocysteine Blood Odds Ratio Confidence Intervals Descriptive Statistics Chinese Persons Homocysteine Adenosine Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Background and project: Non-alcoholic fatty liver disease (NAFLD) is viewed as the hepatic manifestation of metabolic syndrome. Methionine metabolites have been linked to metabolic syndrome and its related diseases. Whether serum methionine metabolites levels are associated with NAFLD remains unclear. The study aimed to assess the association between methionine metabolites and NAFLD. Methods: This cross-sectional study included a total of 2814 individuals aged 40–75 years old. All participants underwent anthropometric measurements, laboratory tests, dietary assessment and abdominal ultrasonography. Multivariable logistic regression analysis was performed to estimate the association of methionine metabolites with NAFLD. Results: Overall, 1446 with and 1368 without NAFLD were enrolled in this study. Participants with NAFLD had significantly higher serum S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) and homocysteine (Hcy) levels, and a lower S-adenosylmethionine/S-adenosylhomocysteine (SAM/SAH) ratio than those without NAFLD (all P < 0.001). After adjusting multiple confounders, odds ratios (95% confidence interval) for quartile 4 versus quartile 1 of SAH, Hcy and SAM/SAH ratio were 1.65 (1.27–2.14), 1.63 (1.26–2.12) and 0.63 (0.49–0.83), respectively (all P for trend < 0.01). In addition, serum SAH, Hcy levels and SAM/SAH ratio were significantly correlated with the degree of hepatic steatosis (all P for trend < 0.001). Conclusion: Elevated serum SAH, Hcy levels and lower SAM/SAH ratio may be independently associated with the presence of NAFLD in middle-aged and elder Chinese. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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