Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.

Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity...

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Publicado en:AIDS & Behavior Vol. 26; no. 6; pp. 1966 - 1980
Autores principales: Saloner, Rowan, Lobo, Judith D., Paolillo, Emily W., Campbell, Laura M., Letendre, Scott L., Cherner, Mariana, Grant, Igor, Heaton, Robert K., Ellis, Ronald J., Roesch, Scott C., Moore, David J., for the CHARTER Study Group, Marcotte, Thomas D., Franklin Jr., Donald, McCutchan, J. Allen, Smith, Davey M., Atkinson, J. Hampton, Dawson, Matthew, Fennema-Notestine, Christine, Taylor, Michael J.
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jun2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2022
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10461-021-03546-9
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      ppf: 1966
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        atl: Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.
      aug:
        au:
          Saloner, Rowan
          Lobo, Judith D.
          Paolillo, Emily W.
          Campbell, Laura M.
          Letendre, Scott L.
          Cherner, Mariana
          Grant, Igor
          Heaton, Robert K.
          Ellis, Ronald J.
          Roesch, Scott C.
          Moore, David J.
          for the CHARTER Study Group
          Marcotte, Thomas D.
          Franklin Jr., Donald
          McCutchan, J. Allen
          Smith, Davey M.
          Atkinson, J. Hampton
          Dawson, Matthew
          Fennema-Notestine, Christine
          Taylor, Michael J.
        affil: San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA
      sug:
        subj:
          Neuropsychology
          HIV-Positive Persons Psychosocial Factors
          Human
          Multicenter Studies
          Models, Biopsychosocial
          Criterion-Related Validity
          Comorbidity
          Prospective Studies
          Middle Age
          Aged
          Construct Validity
          Neuropsychological Tests
          Psychosocial Functioning
          Middle Aged: 45-64 years
          Aged: 65+ years
      ab:
        Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1–5 years of follow-up. Classes were defined using 'peak-age' global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1Stable Elite (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2Quadratic Average (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3Quadratic Low (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1Stable Elite included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health.
        Resumen: A pesar de los riesgos neurocognitivos de envejecer con VIH, datos transversales iniciales sugieren que una subpoblación de personas con VIH (PCV) de edad mayor posee neurocognición (NC) juvenil, característica de los Súper-Ancianos (SA). Aquí nosotros caracterizamos trayectorias longitudinales de NC en PCV mayores y su validez convergente con su status de referencia de SA, según los criterios establecidos en PCV, y factores biopsicosociales en la base de referencia. El modelo de mezclas Gaussianas (GMM) identificó clases longitudinales de NC en 184 PCV mayores (edad ≥ 50-años) con 1–5 años de seguimiento. Las clases fueron definidas utilizando puntuaciones-T (T-scores) globales de "edad pico", que comparan el desempeño con una muestra normativa de personas de 25 años de edad. 3-clases fueron identificadas: Clase 1Élite Estable (n = 31 [16.8%], puntuaciones-T de edad pico de referencia altas con trayectoria plana; Clase 2Promedio Cuadrático (n = 100 [54.3%], puntuaciones-T de edad pico de referencia intermedias con trayectoria en forma de u); Clase 3Cuadrática Baja (n = 53 [28.8%], %], puntuaciones-T de edad pico de referencia bajas con trayectoria en forma de u). Los predictores de referencia de la Clase 1Élite Estable incluyen estatus de SA, edad mas joven, reserva cognitiva y fisiológica superior, y menos dificultades cognitivas subjetivas. Este análisis GMM apoya la validez del constructo de Súper-Envejecimiento en PCV mayores mediante la identificación de un subgrupo longitudinalmente estable, neurocognición juvenil y una robusta salud biopsicosocial.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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