Executive function deficits in mild cognitive impairment: evidence from saccade tasks.
Early detection of mild cognitive impairment (MCI) is necessary to prevent irreversible brain damage caused by incipient Alzheimer's disease. It has been showing that amnestic MCI (a-MCI) subjects exhibit subtle deficits in executive function that can be tested using saccade eye movements. Eye-track...
| Published in: | Aging & Mental Health Vol. 26; no. 5; pp. 1001 - 1010 |
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| Main Authors: | , , , |
| Format: | Article |
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Taylor & Francis Ltd
May2022
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=156553864&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 156553864 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 13607863 57E jtl: Aging & Mental Health issn: 13607863 maglogo: N pubinfo: dt: May2022 vid: 26 iid: 5 pid: 377 pub: Taylor & Francis Ltd artinfo: ui: 156553864 10.1080/13607863.2021.1913471 ppf: 1001 ppct: 9 formats: tig: atl: Executive function deficits in mild cognitive impairment: evidence from saccade tasks. aug: au: Chehrehnegar, Negin Shati, Mohsen Esmaeili, Mahdieh Foroughan, Mahshid affil: Linnaeus Centre HEAD, Swedish Institute for Disability Research, Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden Mental Health Research Center, School of Behavioural Sciences and Mental Health, Tehran Institute of Psychiatry, Iran University of Medical Sciences (IUMS), Tehran, Iran Iranian Research Center on Aging, Gerontology and Geriatric Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran su: Executive function Technology Saccadic eye movements Alzheimer's disease Mild cognitive impairment Eye movement measurements Dementia Short-term memory Amnesia sug: subj: Executive function Technology Saccadic eye movements Alzheimer's disease Mild cognitive impairment Eye movement measurements Dementia Short-term memory Amnesia keyword: Aging Alzheimer disease executive function eye movements mild cognitive impairment saccade Aging Alzheimer disease executive function eye movements mild cognitive impairment saccade ab: Early detection of mild cognitive impairment (MCI) is necessary to prevent irreversible brain damage caused by incipient Alzheimer's disease. It has been showing that amnestic MCI (a-MCI) subjects exhibit subtle deficits in executive function that can be tested using saccade eye movements. Eye-tracking technology is a sensitive method to measure cognitive impairments in dementia and MCI. In this study, we used eye-tracking technology to explore saccade impairments to distinguish between a-MCI and the variants of reference controls. 21 patients with AD, 40 patients with a-MCI, and 59 normal participants were recruited in current study. We measured saccade reaction time, saccade errors, saccade omission, and uncorrected saccades using anti-saccade and pro-saccade tasks with 'gap' and 'overlap' procedures. These parameters were used as markers of executive function and visual attention deficits.Results: The findings revealed that more errors, more omissions, and fewer corrections characterized the saccade behavior of the a-MCI group compared to the reference group. These eye-tracking characteristics can be considered as inhibitory control and working memory deficits in a-MCI subjects. Our results thus demonstrate the applicability of the anti-saccade task as a cognitive marker in a-MCI. The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of executive function in aging with cognitive impairments. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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