Comparing Serum Levels of Autophagy-Related Gene 5 in People With and Without Helicobacter Pylori Infection.
Background Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) can increase autophagy. Disruption in this process can cause various diseases, including cancer. Objective This study aims to compare the serum level of Autophag -Related Gene 5 (ATG...
| Publicado en: | Journal of Guilan University of Medical Sciences Vol. 30; no. 4; pp. 258 - 267 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Journal of Guilan University of Medical Sciences
Winter2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156559442&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156559442 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20084048 EVAI jtl: Journal of Guilan University of Medical Sciences issn: 20084048 maglogo: N pubinfo: dt: Winter2022 vid: 30 iid: 4 pid: 76615 pub: Journal of Guilan University of Medical Sciences artinfo: ui: 156559442 156559442 156559442 10.32598/JGUMS.30.4.1748.1 156559442 ppf: 258 ppct: 9 formats: tig: atl: Comparing Serum Levels of Autophagy-Related Gene 5 in People With and Without Helicobacter Pylori Infection. aug: au: Joukar, Farahnaz Afshar, Iman Soufi Yeganeh, Sara Naghipour, Mohammad Reza Mansour-Ghanaei, Alireza Mansour-Ghanaei, Fariborz affil: Guilan Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. sug: subj: Helicobacter Infections Autophagy-Related Proteins Blood Genes Case Control Studies Pilot Studies Endoscopy Iran Adult Middle Age Enzyme-Linked Immunosorbent Assay Urease Male Female Age Factors Body Mass Index Sex Factors Data Analysis Software Descriptive Statistics Confidence Intervals Odds Ratio Human Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) can increase autophagy. Disruption in this process can cause various diseases, including cancer. Objective This study aims to compare the serum level of Autophag -Related Gene 5 (ATG5 ) in individuals with and without H. pylori infection. Methods This case-control pilot study was conducted in 2018 on 44 individuals aged 35-50 years referred to the endoscopy ward of Razi Hospital in Rasht, Iran. Their age, gender, Body Mass Index (BMI), smoking, and symptoms were first recorded in a form. Based on Rapid Urease Test and pathology results, they included in two groups of patient (n=22) and healthy (n=22). Serum ATG5 levels were quantitatively assessed by an ELISA kit (EIAab, USA). Results Most of participants (56.8%) were male, aged over 40 years (77.3%), a BMI < 25 kg/m2 (52.3%) and not smoking cigarettes (70.5%). The mean serum levels of ATG5 in individuals with and without H. pylori infections were 63.5 ± 15.4 and 57.1±18.9, respectively (P>0.05). The mean ATG5 level was higher in women than in men (P= 0.0047). Conclusion Serum level of ATG5 is not significantly different between people with and without H. pylori infection. Further study is recommended using a larger sample size and based on a comparing gastrointestinal lesions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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