Investigation of the relationship between community-acquired respiratory distress syndrome toxin and the high-mobility group box protein 1-toll-like receptors-myeloid differentiation factor 88 signaling pathway in Mycoplasma pneumoniae pneumonia.
Background: In recent years, reports of refractory Mycoplasma pneumoniae pneumonia (RMPP) have gradually increased, including reports on how these conditions threaten the lives of children. However, the specific mechanism of Mycoplasma pneumoniae pneumonia (MPP) remains unclear. This study aimed to...
| Publicado en: | Italian Journal of Pediatrics Vol. 48; no. 1; pp. 1 - 7 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
5/3/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156643073&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156643073 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17208424 1D4R jtl: Italian Journal of Pediatrics issn: 17208424 maglogo: N pubinfo: dt: 5/3/2022 vid: 48 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 156643073 156643073 156643073 10.1186/s13052-022-01254-1 156643073 ppf: 1 ppct: 6 formats: tig: atl: Investigation of the relationship between community-acquired respiratory distress syndrome toxin and the high-mobility group box protein 1-toll-like receptors-myeloid differentiation factor 88 signaling pathway in Mycoplasma pneumoniae pneumonia. aug: au: Fan, Yujie Ding, Ying Li, Yuqin Zhang, Dandan Yu, Min Zhou, Wei-fang Kong, Xiaoxing affil: Department of Infectious Disease, Children's Hospital of Soochow University, Soochow University, 215003, Suzhou, China sug: subj: Gene Expression Respiratory Distress Syndrome, Acute Bacterial Toxins Bacterial Proteins Pneumonia, Mycoplasma Toll-Like Receptors Receptors, Cell Surface Signal Transduction Human Bronchoscopy Descriptive Statistics Male Female Child Child, Preschool Pneumonia Signs and Symptoms Polymerase Chain Reaction Quantitative Studies Comparative Studies Tumor Necrosis Factor Enzyme-Linked Immunosorbent Assay Data Analysis Software T-Tests Pearson's Correlation Coefficient Correlation Coefficient Chi Square Test Child: 6-12 years Child, Preschool: 2-5 years Male Female ab: Background: In recent years, reports of refractory Mycoplasma pneumoniae pneumonia (RMPP) have gradually increased, including reports on how these conditions threaten the lives of children. However, the specific mechanism of Mycoplasma pneumoniae pneumonia (MPP) remains unclear. This study aimed to investigate the relationship between community-acquired respiratory distress syndrome toxin (CARDS TX) and High-mobility group box protein 1-Toll-like receptors-Myeloid differentiation factor 88 (HMGB1-TLRs-MyD88) in MPP and to examine the immune pathogenesis of Mycoplasma pneumoniae infection. Methods: Children who were diagnosed with MPP and examined by bronchoscopy were included in the MPP group. Additionally, children who underwent bronchoscopy because of bronchial foreign bodies in the same period were included in the control group. Gene expression of CARDS TX, HMGB1, Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), MyD88, and cluster of differentiation 14 (CD14) in bronchoalveolar lavage fluid (BALF) were detected using real-time reverse transcription-polymerase chain reaction. Correlations between CARDS TX and HMGB1-TLRs-MyD88 were analyzed. Results: CARDS TX, HMGB1, TLR2, MyD88, and CD14 mRNA expression in BALF in the MPP group was significantly higher than that in the control group (all P < 0.05). CARDS TX mRNA expression was positively correlated with HMGB1, TLR2, MyD88, and CD14 mRNA expression (all P < 0.05). Furthermore, HMGB1 mRNA expression was positively correlated with TLR2, MyD88, and CD14 mRNA expression (all P < 0.05). Conclusions: CARDS TX may participate in the immune pathogenesis of MPP through the HMGB1-TLRs/CD14-MyD88 pathway. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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