Sex and age differences in approach behavior toward a port that delivers nicotine vapor.
The goal of our laboratory is to study the mechanisms that promote nicotine use, particularly in vulnerable populations. To more closely mimic human use patterns, the present study employed nicotine vapor methods involving passive exposure for 14 days in adolescent and adult female and male rats. Ag...
| Publicado en: | Journal of the Experimental Analysis of Behavior Vol. 117; no. 3; pp. 532 - 543 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
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Wiley-Blackwell
May2022
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=156769411&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 156769411 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00225002 JOE jtl: Journal of the Experimental Analysis of Behavior issn: 00225002 maglogo: Y pubinfo: dt: May2022 vid: 117 iid: 3 pid: 480 pub: Wiley-Blackwell artinfo: ui: 156769411 10.1002/jeab.756 ppf: 532 ppct: 11 formats: tig: atl: Sex and age differences in approach behavior toward a port that delivers nicotine vapor. aug: au: Espinoza, Veronika E. Giner, Priscilla Liano, Isabella Mendez, Ian A. O'Dell, Laura E. affil: Department of Psychology, The University of Texas at El Paso Department of Pharmaceutical Sciences, The University of Texas at El Paso su: Age differences Teenage girls Approach behavior Nicotine Cotinine Drug withdrawal symptoms sug: subj: Age differences Teenage girls Medicinal and Botanical Manufacturing Approach behavior Nicotine Cotinine Drug withdrawal symptoms keyword: e‐cigarette motivation plumes rat reward e‐cigarette motivation plumes rat reward ab: The goal of our laboratory is to study the mechanisms that promote nicotine use, particularly in vulnerable populations. To more closely mimic human use patterns, the present study employed nicotine vapor methods involving passive exposure for 14 days in adolescent and adult female and male rats. Age and sex differences in approach behavior (nosepokes) were assessed in a port that delivered nicotine plumes on Day 1 and 14 of our exposure regimen. Controls received ambient air in exposure chambers. After the final session, rats received a nicotinic receptor antagonist to precipitate withdrawal. Then, physical signs, anxiety‐like behavior, and plasma levels of cotinine (a nicotine metabolite) were assessed. Over time, females displayed a larger increase in approach behavior to the nicotine port than males, an effect that was larger in adolescents. Nosepoke responses in adolescent females were correlated with anxiety‐like behavior, but not physical signs of withdrawal. Adolescents gained more weight than adults regardless of treatment, and the weight gain was larger in male adolescents. Female adolescents also displayed the highest levels of cotinine than all other groups. These findings suggest that nicotine vapor produces greater motivational effects in adolescent females as compared to their adult and male counterparts. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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