Pretreatment Nutrition-Inflammation Biomarkers Correlated with Differential Cytokine Profiles in Taiwanese Patients with Colorectal Cancer.
Systemic inflammation plays a pivotal role in colorectal cancer (CRC) development. Two hallmarks reflect the severity of inflammation—circulating cytokines and nutrition-inflammation biomarkers (NIBs); however, their interplay has not been fully investigated. In total, 128 CRC patients were included...
| Publicado en: | Nutrition & Cancer Vol. 74; no. 5; pp. 1614 - 1625 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156835411&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156835411 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 156835411 151655198 156835411 156835411 10.1080/01635581.2021.1957130 156835411 ppf: 1614 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pretreatment Nutrition-Inflammation Biomarkers Correlated with Differential Cytokine Profiles in Taiwanese Patients with Colorectal Cancer. aug: au: Yu, Yen-Lin Tseng, Wen-Ko Fan, Chung-Wei Chang, Pei-Hung Kuo, Hsuan-Chih Pan, Yi-Ping Yeh, Kun-Yun affil: Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan sug: subj: Colorectal Neoplasms Cytokines Blood Inflammation Inflammation Mediators Biological Markers Human Taiwan Female Male Retrospective Design Cancer Patients Tumor Necrosis Factor Analysis Interleukins Analysis C-Reactive Protein Neutrophil Lymphocyte Ratio Transforming Growth Factor beta Analysis Medical Records Logistic Regression Body Mass Index Statistical Significance Cox Proportional Hazards Model Univariate Statistics Multivariate Analysis Correlation Coefficient Survival Analysis Descriptive Statistics Data Analysis Software Adolescence Young Adult Adult Middle Age Aged Aged, 80 and Over Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Systemic inflammation plays a pivotal role in colorectal cancer (CRC) development. Two hallmarks reflect the severity of inflammation—circulating cytokines and nutrition-inflammation biomarkers (NIBs); however, their interplay has not been fully investigated. In total, 128 CRC patients were included. Ten circulating cytokines (TNF-α, TGF-β, IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12, IL-13, and IL-23) and NIBs were analyzed. The relationship between cytokines, NIBs, clinicopathological variables, and overall survival (OS) was assessed using univariate and multivariate analyses. Three NIBs (CRP-to-albumin ratio [CAR]), neutrophil-to-lymphocyte ratio [NLR]), and prognostic nutritional index [PNI]) were associated with OS in univariate analysis; however, CAR was better for OS prediction in multivariate analysis (P = 0.015). None of the serum cytokines analyzed showed a significant association with OS. High CAR (≥0.25) and high IL-10 (≥76.6 pg/mL), high NLR (≥8.2) and high IL-23 (≥51.2 pg/mL), and high PNI (≥42.4) and high IL-1β (≥14.3 pg/mL) values were correlated. CAR, NLR, and PNI were not correlated with each other, whereas circulating cytokines were closely interrelated. High CAR was an independent predictor of poor OS in patients with CRC. Different NIBs have unique cytokine profiles, but show no correlation with each other. There is a close association among the circulating cytokines. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|