Maternal Plasma 25-Hydroxyvitamin D during Gestation Is Positively Associated with Neurocognitive Development in Offspring at Age 4-6 Years.
Background: Vitamin D is critical to embryonic neuronal differentiation and other developmental processes that may affect future neurocognitive function. However, observational studies have found inconsistent associations between gestational vitamin D and neurocognitive outcomes. Objectives: We exam...
| Publicado en: | Journal of Clinical Chiropractic Pediatrics Vol. 20; no. 1; pp. 132 - 140 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
International Chiropractors Association, Council on Chiropractic Pediatrics
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156854957&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156854957 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23726180 FTGN jtl: Journal of Clinical Chiropractic Pediatrics issn: 23726180 maglogo: N pubinfo: dt: 2021 vid: 20 iid: 1 pid: 35119 pub: International Chiropractors Association, Council on Chiropractic Pediatrics place: Falls Church, Virginia artinfo: ui: 156854957 156854957 156854957 10.1093/jn/nxaa309 156854957 ppf: 132 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Maternal Plasma 25-Hydroxyvitamin D during Gestation Is Positively Associated with Neurocognitive Development in Offspring at Age 4-6 Years. aug: au: Melough, Melissa M. Murphy, Laura E. Graff, J. Carolyn Derefinko, Karen J. LeWinn, Kaja Z. Bush, Nicole R. Enquobahrie, Daniel A. Loftus, Christine T. Kocak, Mehmet Sathyanarayana, Sheela Tylavsky, Frances A. affil: Department of Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, USA sug: subj: Vitamin D Blood Cognition Child Development Pregnancy Female Human Nonexperimental Studies Multiple Linear Regression Vitamin D Deficiency Prenatal Nutritional Physiology Female ab: Background: Vitamin D is critical to embryonic neuronal differentiation and other developmental processes that may affect future neurocognitive function. However, observational studies have found inconsistent associations between gestational vitamin D and neurocognitive outcomes. Objectives: We examined the association of gestational 25-hydroxyvitamin D [25(OH)D] with children's IQ at 4-6 y, and explored whether associations differed by race. Methods: This study used data from the CANDLE (Conditions Affecting Neurocognitive Development and Learning in Early Childhood) cohort. Between 2006 and 2011, CANDLE recruited 1503 women in their second trimester of healthy singleton pregnancies. Inclusion criteria for this analysis were gestation of =34 wk and availability of 25(OH)D and IQ data. Associations between second-trimester 25(OH)D plasma concentration and Stanford-Binet IQ scores in offspring at 4-6 y were examined using multivariable linear regression; interaction terms were used to explore possible effect modification by race. Results: Mean ± SD 25(OH)D concentration among 1019 eligible dyads was 21.6 ± 8.4 ng/mL, measured at a mean ± SD gestational age of 23.0 ± 3.0 wk. Vitamin D deficiency [25(OH)D < 20 ng/mL] was observed in 45.6%. Maternal 25(OH)D differed by race with a mean ± SD of 19.8 ± 7.2 ng/mL in Blacks sand 25.9 ± 9.3 ng/mL in Whites (P < 0.001). In adjusted models a 10-ng/mL increase in 25(OH)D was associated with a 1.17-point higher Full Scale IQ (95% CI: 0.27, 2.06 points), a 1.17-point higher Verbal IQ (95% CI: 0.19, 2.15 points), and a 1.03-point higher Nonverbal IQ (95% CI: 0.10, 1.95 points). We observed no evidence of effect modification by race. Conclusions: Second-trimester maternal 25(OH)D was positively associated with IQ at 4-6 y, suggesting that gestational vitamin D status may be an important predictor of neurocognitive development. These findings may help inform prenatal nutrition recommendations and may be especially relevant for Black and other dark-skinned women at high risk of vitamin D deficiency. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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