Characterizing the temporal changes in association between modifiable risk factors and acute kidney injury with multi-view analysis.
Background: Acute kidney injury (AKI) is a common life-threatening clinical syndrome in hospitalized patients. Advances in machine learning has demonstrated success in AKI risk prediction using electronic health records (EHRs). However, to prevent AKI, it is critical to identify clinically modifiabl...
| Publicado en: | International Journal of Medical Informatics Vol. 163 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156901198&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156901198 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13865056 JR4 jtl: International Journal of Medical Informatics issn: 13865056 maglogo: N pubinfo: dt: Jul2022 vid: 163 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 156901198 156901198 NLM35504130 156901198 10.1016/j.ijmedinf.2022.104785 NLM35504130 156901198 ppct: 1 formats: tig: atl: Characterizing the temporal changes in association between modifiable risk factors and acute kidney injury with multi-view analysis. aug: au: Liu, Kang Yuan, Borong Zhang, Xiangzhou Chen, Weiqi Patel, Lav P. Hu, Yong Liu, Mei affil: Big Data Decision Institute, Jinan University, Guangzhou, Guangdong, China sug: subj: Kidney Failure, Acute Prevention and Control Kidney Failure, Acute Epidemiology Risk Factors Algorithms Retrospective Design Impact of Events Scale Scales Social Readjustment Rating Scale ab: Background: Acute kidney injury (AKI) is a common life-threatening clinical syndrome in hospitalized patients. Advances in machine learning has demonstrated success in AKI risk prediction using electronic health records (EHRs). However, to prevent AKI, it is critical to identify clinically modifiable factors and understand their impact at different prevention windows.Method: We extracted 4129 clinical variables including demographics, social history, past diagnoses, procedures, labs, medications, vitals from EHRs for a cohort of 144,084 eligible inpatient encounters. We developed a multi-view learning framework for XGBoost (MV-XGB) to enhance algorithm attention on modifiable factors. To study effects of modifiable factors at different time points, we built AKI prediction models at 24-hours, 48-hours, 72-hours before AKI onset. To characterize the temporal changes in effect of modifiable factors on AKI, we derived two indicators, inter-class score-difference and exposed-score-difference, based on SHAP values to compare effects of modifiable factors in different windows.Result: MV-XGB effectively increased attention on modifiable factors (explained 92.4%-94.1% inter-class score-difference, i.e., predictive difference between AKI and non-AKI samples) while maintaining good predictive performance (AUROCs were 0.854, 0.798, 0.765 in models for 24-48-72 h AKI prediction respectively). We observed that 62% of predicted odds-ratio difference between AKI and non-AKI patients in 24 h can be explained by factors occurring between 24 and 72 h. Among the important modifiable factors, electrolyte balance explained 38.3% of the inter-class score difference increase between 24 h and 72 h, followed by high-risk medications (13.7%), care strategy (12.1%), blood pressure (10%), infection (7.8%), and anemia (5.4%). Effects of cardiac surgery or condition, respiratory ventilation, and anemia remained important longer than 72 h.Conclusion: Better understanding of the clinically modifiable factors is important to AKI prevention. The proposed multi-view learning approach improved the identification of modifiable factors of AKI and allowed characterization of the temporal dynamics of their potential benefit in intervention. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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