Novel benzimidazole derivatives; synthesis, bioactivity and molecular docking study as potent urease inhibitors.
Background: Benzimidazole derivatives are widely used to design and synthesize novel bioactive compounds. There are several approved benzimidazole-based drugs on the market. Objectives: In this study, we aimed to design and synthesize a series of novel benzimidazole derivatives 8a-n that are urease...
| Publicado en: | DARU: Journal of Pharmaceutical Sciences Vol. 30; no. 1; pp. 29 - 38 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156930129&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156930129 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15608115 8WS jtl: DARU: Journal of Pharmaceutical Sciences issn: 15608115 maglogo: N pubinfo: dt: Jun2022 vid: 30 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 156930129 154717712 156930129 156930129 10.1007/s40199-021-00427-3 156930129 ppf: 29 ppct: 9 formats: tig: atl: Novel benzimidazole derivatives; synthesis, bioactivity and molecular docking study as potent urease inhibitors. aug: au: Saeedian Moghadam, Ebrahim Al-Sadi, Abdullah Mohammed Talebi, Meysam Amanlou, Massoud Amini, Mohsen Abdel-Jalil, Raid affil: Department of Chemistry, College of Science, Sultan Qaboos University, P.O. Box 36, P.C. 123, Muscat, Sultanate of Oman sug: subj: Heterocyclic Compounds Analogs and Derivatives Urease Antagonists and Inhibitors Heterocyclic Compounds Pharmacodynamics Drug Design Molecular Docking Simulation Human Toxicity Tests Mass Spectrometry Magnetic Resonance Spectroscopy Cell Line Drug Effects Urease Drug Effects ab: Background: Benzimidazole derivatives are widely used to design and synthesize novel bioactive compounds. There are several approved benzimidazole-based drugs on the market. Objectives: In this study, we aimed to design and synthesize a series of novel benzimidazole derivatives 8a-n that are urease inhibitors. Methods: All 8a-n were synthesized in a multistep. To determine the urease inhibitory effect of 8a-n, the urease inhibition kit was used. The cytotoxicity assay of 8a-n was determined using MTT method. Molecular modelling was determined using autodock software. Results: All 8a-n were synthesized in high yield, and their structures were determined using 1H-NMR, 13C-NMR, MS, and elemental analyses. In compared to thiourea and hydroxyurea as standards (IC50: 22 and 100 µM, respectively), all 8a-n had stronger urease inhibition activity (IC50: 3.36—10.81 µM). With an IC50 value of 3.36 µM, 8e had the best enzyme inhibitory activity. On two evaluated cell lines, the MTT cytotoxicity experiment revealed that all 8a-n have IC50 values greater than 50 µM. Finally, a docking investigation revealed a plausible way of interaction between the 8e and 8d and the enzyme's active site's key residues. Conclusion: The synthesized benzimidazole derivatives exhibit high activity, suggesting that further research on this family of compounds would be beneficial to finding a potent urease inhibitor. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|