Optical tissue clearing associated with 3D imaging: application in preclinical and clinical studies.
Understanding the inner morphology of intact tissues is one of the most competitive challenges in modern biology. Since the beginning of the twentieth century, optical tissue clearing (OTC) has provided solutions for volumetric imaging, allowing the microscopic visualization of thick sections of tis...
| Publicado en: | Histochemistry & Cell Biology Vol. 157; no. 5; pp. 497 - 512 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156932137&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156932137 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09486143 NQI jtl: Histochemistry & Cell Biology issn: 09486143 maglogo: N pubinfo: dt: May2022 vid: 157 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 156932137 155520431 10.1007/s00418-022-02081-5 156932137 ppf: 497 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Optical tissue clearing associated with 3D imaging: application in preclinical and clinical studies. aug: au: Brenna, Cinzia Simioni, Carolina Varano, Gabriele Conti, Ilaria Costanzi, Eva Melloni, Mattia Neri, Luca Maria affil: Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy sug: ab: Understanding the inner morphology of intact tissues is one of the most competitive challenges in modern biology. Since the beginning of the twentieth century, optical tissue clearing (OTC) has provided solutions for volumetric imaging, allowing the microscopic visualization of thick sections of tissue, organoids, up to whole organs and organisms (for example, mouse or rat). Recently, tissue clearing has also been introduced in clinical settings to achieve a more accurate diagnosis with the support of 3D imaging. This review aims to give an overview of the most recent developments in OTC and 3D imaging and to illustrate their role in the field of medical diagnosis, with a specific focus on clinical applications. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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