Alcohol dependence decreases functional activation of the caudate nucleus during model‐based decision processes.
Background: Impaired decision making, a key characteristic of alcohol dependence (AD), manifests in continuous alcohol consumption despite severe negative consequences. The neural basis of this impairment in individuals with AD and differences with known neural decision mechanisms among healthy subj...
| Publicado en: | Alcoholism: Clinical & Experimental Research Vol. 46; no. 5; pp. 749 - 759 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156939538&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156939538 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01456008 IQE jtl: Alcoholism: Clinical & Experimental Research issn: 01456008 maglogo: Y pubinfo: dt: May2022 vid: 46 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 156939538 155948022 156939538 156939538 10.1111/acer.14812 156939538 ppf: 749 ppct: 10 formats: tig: atl: Alcohol dependence decreases functional activation of the caudate nucleus during model‐based decision processes. aug: au: Magrabi, Amadeus Beck, Anne Schad, Daniel J. Lett, Tristram A. Stoppel, Christian M. Charlet, Katrin Kiefer, Falk Heinz, Andreas Walter, Henrik affil: Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany sug: subj: Alcoholism Physiopathology Basal Ganglia Physiology Decision Making Task Performance and Analysis Human Magnetic Resonance Imaging Methods Uncertainty Financial Management Brain Physiology Prefrontal Cortex Physiology Alcohol Drinking ab: Background: Impaired decision making, a key characteristic of alcohol dependence (AD), manifests in continuous alcohol consumption despite severe negative consequences. The neural basis of this impairment in individuals with AD and differences with known neural decision mechanisms among healthy subjects are not fully understood. In particular, it is unclear whether the choice behavior among individuals with AD is based on a general impairment of decision mechanisms or is mainly explained by altered value attribution, with an overly high subjective value attributed to alcohol‐related stimuli. Methods: Here, we use a functional magnetic resonance imaging (fMRI) monetary reward task to compare the neural processes of model‐based decision making and value computation between AD individuals (n = 32) and healthy controls (n = 32). During fMRI, participants evaluated monetary offers with respect to dynamically changing constraints and different levels of uncertainty. Results: Individuals with AD showed lower activation associated with model‐based decision processes in the caudate nucleus than controls, but there were no group differences in value‐related neural activity or task performance. Conclusions: Our findings highlight the role of the caudate nucleus in impaired model‐based decisions of alcohol‐dependent individuals. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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