Treatment Sequencing Strategies in Lung Cancer.

Background and objective The advances in the lung cancer screening methods and therapeutics, together with awareness towards deleterious habits, such as smoking, is increasing the overall survival with better quality of life for the patients. However, lung cancer is still one of the most common and...

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Publicado en:Chinese Journal of Lung Cancer Vol. 25; no. 5; pp. 323 - 337
Autores principales: Pozza, Daniel Humberto, Bezerra Andrade de Mello, Ramon
Formato: research systematic review tables/charts Journal Article
Publicado: Chinese Journal of Lung Cancer May2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: May2022
      vid: 25
      iid: 5
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      pub: Chinese Journal of Lung Cancer
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        156995011
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        10.3779/j.issn.1009-3419.2022.104.01
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        atl: Treatment Sequencing Strategies in Lung Cancer.
      aug:
        au:
          Pozza, Daniel Humberto
          Bezerra Andrade de Mello, Ramon
        affil: Department of Biomedicine, Faculty of Medicine and i3s, University of Porto, 4200-319 Porto, Portugal
      sug:
        subj:
          Lung Neoplasms Therapy
          Oncologic Care
          Patient Care Plans
          Guideline Adherence
          Human
          Lung Neoplasms Physiopathology
          Histocytochemistry
          Pathology, Molecular
          Immunotherapy
          Antibodies, Monoclonal Therapeutic Use
          Nivolumab Therapeutic Use
          Systematic Review
          PubMed
          Genetic Techniques
      ab: Background and objective The advances in the lung cancer screening methods and therapeutics, together with awareness towards deleterious habits, such as smoking, is increasing the overall survival with better quality of life for the patients. However, lung cancer is still one of the most common and fatal neoplasm with a high incidence and consequently burden to public health worldwide. Thus, based on guidelines and recent phases II and III clinical trials studies, this manuscript summarizes the current treatment sequencing strategies in lung cancer. Methods A comprehensive search of related articles was performed focused on phases II and III clinical trials studies. Results The lung cancer management should take into consideration the tumor characteristics, histology, molecular pathology and be discussed in a multidisciplinary team. Lung cancer treatment options comprises surgery whenever possible, radiotherapy associate with/or chemotherapy and immunotherapy as monotherapy, or combined with chemotherapy and best palliative care. Conclusions The screening predictability in more patients, smoking reduction, early diagnosis, better disease understanding and individualized, more effective and tolerable therapeutics are related to an increasing in overall survival and quality of life. In the near future improvement of personalized therapy in precision medicine is expected, enhancing new predictive biomarkers, optimal doses and optimal treatment sequencing as well as anti-cancer vaccines development.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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