An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations.
N-acetylcysteine (NAC) is considered as the body's major antioxidant molecules with diverse biological properties. In this review, the pharmacokinetics, safety and efficacy report on both the preclinical and clinical summary of NAC is discussed. Both in vitro and in vivo preclinical studies along wi...
| Published in: | Journal of Basic & Clinical Physiology & Pharmacology Vol. 33; no. 3; pp. 223 - 234 |
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| Main Authors: | , , , , , , , |
| Format: | pictorial review tables/charts Journal Article |
| Published: |
De Gruyter
May2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157005368&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157005368 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07926855 50E5 jtl: Journal of Basic & Clinical Physiology & Pharmacology issn: 07926855 maglogo: N pubinfo: dt: May2022 vid: 33 iid: 3 pid: 1734 pub: De Gruyter place: , <Blank> artinfo: ui: 157005368 148925691 157005368 157005368 10.1515/jbcpp-2020-0099 157005368 ppf: 223 ppct: 11 formats: tig: atl: An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations. aug: au: Rind, Laiba Ahmad, Mohammad Khan, Mohammad Irfan Badruddeen Akhtar, Juber Ahmad, Usama Yadav, Chandan Owais, Mohammad affil: Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India sug: subj: Acetylcysteine Adverse Effects Acetylcysteine Pharmacokinetics Antioxidants Pharmacokinetics Drug Efficacy Evaluation Molecular Docking Simulation Chemistry, Analytical Drug Evaluation, Preclinical Chromatography, High Pressure Liquid Acetylcysteine Administration and Dosage Drug Development Diabetic Nephropathies Drug Therapy Alzheimer's Disease Drug Therapy Schizophrenia Drug Therapy Colitis, Ulcerative Drug Therapy Mass Spectrometry ab: N-acetylcysteine (NAC) is considered as the body's major antioxidant molecules with diverse biological properties. In this review, the pharmacokinetics, safety and efficacy report on both the preclinical and clinical summary of NAC is discussed. Both in vitro and in vivo preclinical studies along with the clinical data have shown that NAC has enormous biological properties. NAC is used in the treatment of acetaminophen poisoning, diabetic nephropathy, Alzheimer's disease, schizophrenia, and ulcerative colitis, etc. Numerous analytical techniques, for instance, UPLC, LC-MS, HPLC, RP-IPC are primarily employed for the estimation of NAC in different single and fixed-dose combinations. The molecular docking studies on NAC demonstrate the binding within Sudlow's site-I hydrogen bonds and formation of NAC and BSA complexes. Various hydrophobic and hydrophilic amino acids generally exist in making contact with NAC as NAC-BSA complexes. Docking studies of NAC with the active site of the urease exposed an O-coordinated bond through nickel 3002 and a hydrogen bond through His-138. NAC and its analogs also made the allosteric pockets that helped to describe almost all favorable pose for the chaperone in a complex through the protein. Thus, we intended to highlight the several health benefits of this antioxidant compound and applications in pharmaceutical product development. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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