Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses.
INTRODUCTION Most previous studies have examined the effects of acute psychological stress in humans based on select gene panels. The genomic approach may help identify novel genes that underline biological mechanisms of acute psychological stress responses. OBJECTIVE This exploratory study aimed to...
| Published in: | MEDICC Review Vol. 24; no. 2; pp. 35 - 43 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Medical Education Cooperation with Cuba
Apr2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157067239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157067239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15273172 903V jtl: MEDICC Review issn: 15273172 maglogo: N pubinfo: dt: Apr2022 vid: 24 iid: 2 pid: 54282 pub: Medical Education Cooperation with Cuba place: Oakland, California artinfo: ui: 157067239 157067239 157067239 10.37757/mr2022.v24.n2.6 157067239 ppf: 35 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses. aug: au: Logan, Jeongok G. Sijung Yun Teachman, Bethany A. Yongde Bao Farber, Emily Farber, Charles R. affil: Associate professor, University of Virginia School of Nursing, Charlottesville, Virginia, USA sug: subj: Stress, Psychological Physiopathology Genome, Human Gene Expression Evaluation RNA, Messenger Analysis Human Exploratory Research Female Young Adult Adult Psychological Tests Hemodynamics Sequence Analysis Adult: 19-44 years Female ab: INTRODUCTION Most previous studies have examined the effects of acute psychological stress in humans based on select gene panels. The genomic approach may help identify novel genes that underline biological mechanisms of acute psychological stress responses. OBJECTIVE This exploratory study aimed to investigate genome-wide transcriptional activity changes in response to acute psychological stress. METHODS The sample included 40 healthy women (mean age 31.4 ± 11.6 years). Twenty-two participants had a stress experience induced by the Trier Social StressTest (experimental group) and 18 did not (control group). Psychological stress levels and hemodynamic changes were assessed before and after the Trier Social Stress Test. Peripheral blood samples obtained before and after the Trier Social Stress Test were processed for mRNA sequencing. RESULTS Psychological and hemodynamic stress parameters indicated that the Trier Social Stress Test induced moderate levels of stress in the experimental group. Six genes (HCG26, HCP5, HLA-F, HLA-F-AS1, LOC1019287, and SLC22A16) were up-regulated, and Ave genes (CA1, FBXO9, SNCA, STRADB, and TRMT12) were down-regulated among those who experienced stress induction, compared with the control group. Nine genes of eleven were linked to endocrine system disorders, neurological disease, and organismal injury and abnormalities. CONCLUSION Of the genes identified in this study, HCP5, SLC22A16, and SNCA genes have previously been proposed as therapeutic targets for cancer and Parkinson disease. Further studies are needed to examine pathological mechanisms through which these genes mediate effects of psychological stress on adverse health outcomes. Such studies may ultimately identify therapeutic targets that enhance biological resilience to adverse effects of psychological stress. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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