Assessment of Brain Function in Patients With Cognitive Impairment Based on fNIRS and Gait Analysis.
Background: Early detection of mild cognitive impairment is crucial in the prevention of Alzheimer's disease (AD). This study aims to explore the changes in gait and brain co-functional connectivity between cognitively healthy and cognitively impaired groups under dual-task walking through the funct...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 13 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
5/24/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157071533&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157071533 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 5/24/2022 vid: 14 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 157071533 157071533 157071533 10.3389/fnagi.2022.799732 157071533 ppf: 1 ppct: 12 formats: tig: atl: Assessment of Brain Function in Patients With Cognitive Impairment Based on fNIRS and Gait Analysis. aug: au: Wang, Zehua Ren, Ke Li, Deyu Lv, Zeping Li, Xiang He, Xiaoli Wang, Daifa Jiang, Wenyu affil: Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China sug: subj: Brain Physiology Mild Cognitive Impairment Diagnosis Gait Analysis Equipment and Supplies Spectroscopy, Near-Infrared Methods Task Performance and Analysis Human Adult Clinical Assessment Tools Functional Connectivity Scales Middle Age Aged Aged, 80 and Over T-Tests Mann-Whitney U Test Data Analysis Software Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Background: Early detection of mild cognitive impairment is crucial in the prevention of Alzheimer's disease (AD). This study aims to explore the changes in gait and brain co-functional connectivity between cognitively healthy and cognitively impaired groups under dual-task walking through the functional near-infrared spectroscopy (fNIRS) and gait analysis devices. Method: This study used fNIRS device and gait analysis devices to collect the data of 54 older adults. According to the Mini-mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) scales, the older adults were cognitively healthy (control group) and cognitively impaired (experimental group), of which 38 were in the control group and 16 were in the experimental group. The experiment was divided into a total of three sets of task experiments: a walking-only experiment, a dual-task walking-easy (DTW-easy) experiment, and a dual-task walking-difficult (DTW-difficult) experiment. Main Result: For the cognitively impaired and cognitively healthy populations, there were no significant differences in overall functional connectivity, region of interest (ROI) connection strength, and gait performance during single-task walking between the two groups.Whereas the performances of DTW differed significantly from the single-task walking in terms of between-group variability of functional connectivity strength change values, and ROI connection strength change values in relation to the dual-task cost of gait. Finally, the cognitively impaired group was significantly more affected by DTW-difficult tasks than the cognitively healthy group. Conclusion: This study provides a new approach to assist in the diagnosis of people with cognitive impairment and provides a new research pathway for the identification of cognitive impairment. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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