Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET.
Purpose: To investigate taste and smell function in survivors, with a minimum of 2 years since treatment of childhood medulloblastoma (MB)/central nervous system supratentorial primitive neuroectodermal tumor (CNS-PNET).Methods: This cross-sectional study included 40 survivors treated ≤ 20 years of...
| Publicado en: | Supportive Care in Cancer Vol. 30; no. 7; pp. 6155 - 6163 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157099348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157099348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Jul2022 vid: 30 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157099348 157099348 NLM35426047 10.1007/s00520-022-07048-9 NLM35426047 157099348 ppf: 6155 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET. aug: au: Tanem, Kristine Eidal Stensvold, Einar Wilberg, Petter Skaare, Anne B. Singh, Preet Bano Brandal, Petter Herlofson, Bente Brokstad affil: Dep. of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway sug: ab: Purpose: To investigate taste and smell function in survivors, with a minimum of 2 years since treatment of childhood medulloblastoma (MB)/central nervous system supratentorial primitive neuroectodermal tumor (CNS-PNET).Methods: This cross-sectional study included 40 survivors treated ≤ 20 years of age. Taste strips with four concentrations of sweet, sour, salt, and bitter were used to assess taste function in all participants. Score from 0 to 16; ≥ 9 normogeusia, < 9 hypogeusia, and complete ageusia which equals no sensation. No sensation of a specific taste quality equals ageusia of that quality. Thirty-two participants conducted smell testing using three subtests of Sniffin' sticks: threshold, discrimination, and identification. Together they yield a TDI-score from 1 to 48; functional anosmia ≤ 16.00, hyposmia > 16.00- < 30.75, normosmia ≥ 30.75- < 41.50, and ≥ 41.50 hyperosmia. Results were compared with normative data. Survivors rated their taste and smell function using a numerical rating scale (NRS) score 0-10.Results: Forty survivors with a mean time since treatment of 20.5 years, 13 (32.5%) were diagnosed with hypogeusia, nine (22.5%) of these being ageusic to one or more taste qualities. Seventeen (53%) of 32 participants were diagnosed with hyposmia. The mean scores of the olfactory subtests, and TDI score were significantly lower than normative data (P < 0.0001). The mean NRS scores of smell and taste function were 7.9 ± 1.5 and 8 ± 1.3, respectively.Conclusion: Our study showed impaired taste and smell function in survivors of childhood MB/CNS-PNET using objective measurements. However, subjective ratings did not reflect objective findings. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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