Linezolid versus omadacycline in diabetic soft tissue infections: a signal of different adjunctive immunological properties?
Recent understanding of antimicrobial chemotherapy has expanded to appreciate significant impacts on the host-pathogen relationship by antibiotics. Omadacycline statistically outperformed linezolid in treating acute bacterial skin and skin structure infections in patients with diabetes mellitus in a...
| Publicado en: | Journal of Antimicrobial Chemotherapy (JAC) Vol. 77; no. 6; pp. 1503 - 1506 |
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| Formato: | Journal Article |
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Oxford University Press / USA
Jun2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157146469&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157146469 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03057453 N5O jtl: Journal of Antimicrobial Chemotherapy (JAC) issn: 03057453 maglogo: N pubinfo: dt: Jun2022 vid: 77 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 157146469 157146469 NLM35141751 157146469 10.1093/jac/dkac030 NLM35141751 157146469 ppf: 1503 ppct: 3 formats: tig: atl: Linezolid versus omadacycline in diabetic soft tissue infections: a signal of different adjunctive immunological properties? aug: au: Sakoulas, George affil: Division of Host-Microbe Systems & Therapeutics, Center for Immunity, Infection & Inflammation, University of California-San Diego School of Medicine , La Jolla, CA, USA sug: subj: Soft Tissue Infections Drug Therapy Skin Diseases, Infectious Drug Therapy Diabetes Mellitus Skin Diseases, Infectious Microbiology Tetracyclines Therapeutic Use Antibiotics Therapeutic Use Impact of Events Scale Scales ab: Recent understanding of antimicrobial chemotherapy has expanded to appreciate significant impacts on the host-pathogen relationship by antibiotics. Omadacycline statistically outperformed linezolid in treating acute bacterial skin and skin structure infections in patients with diabetes mellitus in a recent post-hoc analysis of the OASIS-1 and OASIS-2 clinical trials. This difference may speak directly or indirectly to neutrophil dysfunction in diabetes. Neutrophil dysfunction increases the likelihood of Gram-negative bacterial infection, whereby diabetics may benefit from the broader spectrum of omadacycline compared with linezolid. Indirectly, oxazolidinones like linezolid have been shown to be dependent on neutrophil function, potentially compromising the potency of this drug class in diabetics. Finally, tetracyclines like omadacycline have collateral anti-inflammatory properties that have not been seen in other antibiotic drug classes. These differences may impact clinical outcomes in the treatment of infections that are not predicted by their antimicrobial activities alone, as measured in standard susceptibility testing assays. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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