Error Characterization and Statistical Modeling Improves Circulating Tumor DNA Detection by Droplet Digital PCR.
BACKGROUND: Droplet digital PCR (ddPCR) is a widely used and sensitive application for circulating tumor DNA (ctDNA) detection. As ctDNA is often found in low abundance, methods to separate low-signal readouts from noise are necessary. We aimed to characterize the ddPCR-generated noise and, informed...
| Publicado en: | Clinical Chemistry Vol. 68; no. 5; pp. 657 - 668 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
May2022
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| Acceso en línea: | Ver este registro en EBSCOhost |