Evaluation of Inflammatory Cytokine and Anti Helicobacter Pylori Antibodies in the Pathogenesis of Parkinson's Disease.
BACKGROUND: Parkinson's disease is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigari. Previous studies have shown that Helicobacter pylori (H. pylori) infection is associated with treatment and clinical response to Parkinson's disease. In the...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 14; no. 1; pp. 96 - 103 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jan2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157181198&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157181198 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jan2022 vid: 14 iid: 1 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 157181198 157181198 157181198 10.34172/mejdd.2022.261 157181198 ppf: 96 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Evaluation of Inflammatory Cytokine and Anti Helicobacter Pylori Antibodies in the Pathogenesis of Parkinson's Disease. aug: au: Shamsdin, Seyedeh Azra Khazraei, Hajar Jaberi, Abass Rahimi Zamani, Mozhdeh Monjezi, Mohammad Rafiee affil: Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran sug: subj: Inflammation Cytokines Helicobacter Infections Immunology Antibodies, Bacterial Parkinson Disease Pathology Human Immunoglobulins Blood Tumor Necrosis Factor Interleukins Enzyme-Linked Immunosorbent Assay Male Female Middle Age Aged Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: Parkinson's disease is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia nigari. Previous studies have shown that Helicobacter pylori (H. pylori) infection is associated with treatment and clinical response to Parkinson's disease. In the present study, we aimed to investigate the effect of H. pylori infection in the pathogenesis of Parkinson's disease. METHODS: 75 patients who suffered from Parkinson's disease and H. pylori infection and 91 healthy controls were recruited. All the subjects were evaluated for serum IgM, IgG, and IgA antibodies as well as TNF-α, IL-6, and IL-4 cytokines by Enzyme-Linked ImmunoSorbent Assay (ELISA)methods. RESULTS: The participants included 102 men and 64 women with a mean age of 66 ± 10.2 and 52.6 ± 10.7 years in the patients and control groups, respectively. The level of IgG, TNF-α, IL-6 in the patients with Parkinson's infected with H. pylori was significantly more than that in the control group. In contrast, IgA was significantly lower in patients with Parkinson's disease compared with the control group. CONCLUSION: Probably, persistent infection with H. pylori could be effective in the pathogenesis of Parkinson's disease by dominating the systemic inflammatory profile. It is suggested that pro-inflammatory cytokines followed by H. pylori infection through the promotion of immune response or neurotoxicity might have a role in the pathogenesis of Parkinson's disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|