Evaluation of a 2D UNet-Based Attenuation Correction Methodology for PET/MR Brain Studies.
Deep learning (DL) strategies applied to magnetic resonance (MR) images in positron emission tomography (PET)/MR can provide synthetic attenuation correction (AC) maps, and consequently PET images, more accurate than segmentation or atlas-registration strategies. As first objective, we aim to invest...
| Publicado en: | Journal of Digital Imaging Vol. 35; no. 3; pp. 432 - 446 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157184669&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157184669 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Jun2022 vid: 35 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 157184669 154920313 157184669 157184669 10.1007/s10278-021-00551-1 157184669 ppf: 432 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evaluation of a 2D UNet-Based Attenuation Correction Methodology for PET/MR Brain Studies. aug: au: Presotto, Luca Bettinardi, Valentino Bagnalasta, Matteo Scifo, Paola Savi, Annarita Vanoli, Emilia Giovanna Fallanca, Federico Picchio, Maria Perani, Daniela Gianolli, Luigi De Bernardi, Elisabetta affil: Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy sug: subj: Positron-Emission Tomography Magnetic Resonance Imaging Brain Deep Learning Diagnostic Imaging Standards Human Image Enhancement Fludeoxyglucose F 18 ab: Deep learning (DL) strategies applied to magnetic resonance (MR) images in positron emission tomography (PET)/MR can provide synthetic attenuation correction (AC) maps, and consequently PET images, more accurate than segmentation or atlas-registration strategies. As first objective, we aim to investigate the best MR image to be used and the best point of the AC pipeline to insert the synthetic map in. Sixteen patients underwent a 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) and a PET/MR brain study in the same day. PET/CT images were reconstructed with attenuation maps obtained: (1) from CT (reference), (2) from MR with an atlas-based and a segmentation-based method and (3) with a 2D UNet trained on MR image/attenuation map pairs. As for MR, T1-weighted and Zero Time Echo (ZTE) images were considered; as for attenuation maps, CTs and 511 keV low-resolution attenuation maps were assessed. As second objective, we assessed the ability of DL strategies to provide proper AC maps in presence of cranial anatomy alterations due to surgery. Three 11C-methionine (METH) PET/MR studies were considered. PET images were reconstructed with attenuation maps obtained: (1) from diagnostic coregistered CT (reference), (2) from MR with an atlas-based and a segmentation-based method and (3) with 2D UNets trained on the sixteen FDG anatomically normal patients. Only UNets taking ZTE images in input were considered. FDG and METH PET images were quantitatively evaluated. As for anatomically normal FDG patients, UNet AC models generally provide an uptake estimate with lower bias than atlas-based or segmentation-based methods. The intersubject average bias on images corrected with UNet AC maps is always smaller than 1.5%, except for AC maps generated on too coarse grids. The intersubject bias variability is the lowest (always lower than 2%) for UNet AC maps coming from ZTE images, larger for other methods. UNet models working on MR ZTE images and generating synthetic CT or 511 keV low-resolution attenuation maps therefore provide the best results in terms of both accuracy and variability. As for METH anatomically altered patients, DL properly reconstructs anatomical alterations. Quantitative results on PET images confirm those found on anatomically normal FDG patients. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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