Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC.

Background: Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against solid tumors. This is in part due to the immunosuppressive tumor microenvironment (TME) which limits the activity of tumor-infiltr...

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Publicado en:	Breast Cancer Research Vol. 24; no. 1; pp. 1 - 11
Autores principales:	Harrasser, Micaela, Gohil, Satyen Harish, Lau, Hiu, Della Peruta, Marco, Muczynski, Vincent, Patel, Dominic, Miranda, Elena, Grigoriadis, Kristiana, Grigoriadis, Anita, Granger, David, Evans, Rachel, Nathwani, Amit Chunilal
Formato:	research Journal Article
Publicado:	BioMed Central 6/3/2022
Acceso en línea:	Ver este registro en EBSCOhost