Hyperammonemia syndrome in immunosuppressed individuals.
Purpose Of Review: Hyperammonemia syndrome is an increasingly recognized and often fatal condition that occurs in immunosuppressed individuals, most commonly lung transplant recipients. Growing evidence suggests hyperammonemia syndrome is associated with systemic infections caused by urease-producin...
| Publicado en: | Current Opinion in Infectious Diseases Vol. 35; no. 3; pp. 262 - 269 |
|---|---|
| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jun2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157287557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157287557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09517375 IQU jtl: Current Opinion in Infectious Diseases issn: 09517375 maglogo: N pubinfo: dt: Jun2022 vid: 35 iid: 3 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 157287557 157287557 NLM35665721 157287557 10.1097/QCO.0000000000000828 NLM35665721 157287557 ppf: 262 ppct: 7 formats: tig: atl: Hyperammonemia syndrome in immunosuppressed individuals. aug: au: Roberts, Scott C. Malik, Waleed Ison, Michael G. affil: Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut sug: subj: Gram-Negative Bacterial Infections Complications Metabolic Diseases Etiology Metabolic Diseases Epidemiology Gram-Negative Bacterial Infections Drug Therapy Gram-Negative Bacterial Infections Diagnosis Metabolic Diseases Diagnosis Gram-Negative Bacteria Syndrome Transplant Recipients Immunocompromised Host Funding Source ab: Purpose Of Review: Hyperammonemia syndrome is an increasingly recognized and often fatal condition that occurs in immunosuppressed individuals, most commonly lung transplant recipients. Growing evidence suggests hyperammonemia syndrome is associated with systemic infections caused by urease-producing organisms, namely Ureaplasma spp., an organism unable to grow with routine culturing techniques. This review will summarize the epidemiology and clinical manifestations of hyperammonemia syndrome, as well as diagnostic and management strategies once hyperammonemia syndrome is suspected.Recent Findings: Hyperammonemia syndrome is being described in increasing frequency in the solid organ transplant population. Morbidity and mortality, even with treatment, is high once hyperammonemia syndrome occurs. Surveillance studies indicate the prevalence of lung donor colonization with Ureaplasma spp. is high, suggesting screening and treatment may be of benefit. Antibiotic resistance is common, and rapid diagnostics can facilitate appropriate antimicrobial therapy in the peri-transplant period.Summary: Hyperammonemia syndrome is most commonly seen in lung transplant recipients and has a high mortality rate once it occurs. Screening for Ureaplasma spp. should be considered in all lung transplant donors. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|